Radical cyclization strategies for the formation of ring constrained tricyclic tropane analogues

被引：15
|
作者：
Hoepping, A
George, C
Flippen-Anderson, J
Kozikowski, AP
机构：
[1] Georgetown Univ, Med Ctr, Dept Neurol, Drug Discovery Program, Washington, DC 20007 USA
[2] USN, Struct Matter Lab, Res Lab, Washington, DC 20375 USA
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 39期
关键词：
D O I：
10.1016/S0040-4039(00)01288-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A concise and efficient method for the construction of N,C3-constrained tropane derivatives has been developed. The key step of the reaction sequence involves either a 6- or a 7-trig radical cyclization. (C) 2000 Published by Elsevier Science Ltd.
引用
收藏
页码：7427 / 7432
页数：6
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