Cytomegalovirus and varicella zoster virus seropositivity of Iranian patients with multiple sclerosis: A population-based study

被引：17

作者：

Karampoor, Sajad ^{[1
]}

Zahednasab, Hamid ^{[2
]}

Ramagopalan, Sreeram ^{[3
]}

Mehrpour, Masoud ^{[4
]}

Etemadifar, Masoud ^{[5
]}

Alsahebfosoul, Fereshteh ^{[6
]}

Keyvani, Hossein ^{[1
]}

机构：

[1] Iran Univ Med Sci, Sch Med, Dept Virol, Tehran, Iran

[2] Univ Tehran, Inst Biochem & Biophys, Tehran, Iran

[3] Evidera, London, England

[4] Iran Univ Med Sci IUMS, Firoozgar Clin Res Dev Ctr FCRDC, Firoozgar Hosp, Dept Neurol, Tehran, Iran

[5] Isfahan Univ Med Sci, Fac Med, Dept Neurol, Esfahan, Iran

[6] Isfahan Univ Med Sci, Fac Med, Dept Immunol, Esfahan, Iran

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2017年 / 309卷

关键词：

Cytomegalovirus; Varicella zoster virus; Multiple sclerosis; Elisa; PREVALENCE; INFECTION;

D O I：

10.1016/j.jneuroim.2017.04.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multiple Sclerosis is a demyelinating disease of the central nervous system (CNS) affecting young individuals with age range of 20-40 years of age. The precise mechanism underlying the disease is still unclear. Some viruses have been proposed to play roles in disease causation. In this study, we recruited 800 MS patients along with 1000 healthy individuals to determine the seropositivity of anti-CMV and anti-VZV IgG titers using enzyme linked immunosorbent assay (ELISA). Our results showed significant higher titers of anti-CMV and anti-VZV IgG titers in serum of MS patients with respect to healthy individuals (for both p < 0.001). It seems that CMV and VZV play a key role in MS pathogenesis.

引用

页码：4 / 6

页数：3

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[1] Varicella zoster virus contributes to relapse in patients with multiple sclerosis
[J]. Nature Clinical Practice Neurology, 2008, 4 (6): : 291 - 291
[2] VARICELLA-ZOSTER VIRUS AND MULTIPLE-SCLEROSIS IN A HUTTERITE POPULATION
ROSS, RT
NICOLLE, LE
CHEANG, M
[J]. JOURNAL OF CLINICAL EPIDEMIOLOGY, 1995, 48 (11) : 1319 - 1324
[3] Prevalence and predictors of depression in Iranian patients with multiple sclerosis: a population-based study
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[5] The varicella-zoster virus and multiple sclerosis
Ross, RT
[J]. JOURNAL OF CLINICAL EPIDEMIOLOGY, 1998, 51 (07) : 533 - 535
[6] The participation of varicella zoster virus in relapses of multiple sclerosis
Sotelo, Julio
Ordonez, Graciela
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[7] Varicella-zoster virus at relapses of multiple sclerosis
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[8] Varicella zoster virus in progressive forms of multiple sclerosis
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[9] Multiple sclerosis and varicella zoster virus infection: A review
Marrie, RA
Wolfson, C
[J]. EPIDEMIOLOGY AND INFECTION, 2001, 127 (02): : 315 - 325
[10] Varicella-zoster virus at relapses of multiple sclerosis
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Ordonez, Graciela
Pineda, Benjamin
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