The partial virological response to Tenofovir monotherapy in naive patients with chronic hepatitis B

被引：0
|
作者：
Gedik, Habip [1 ,2 ]
Sonmezisik, Muge [1 ,2 ]
机构：
[1] Univ Hlth Sci, Dept Infect Dis & Clin Microbiol, Istanbul, Turkey
[2] Minist Hlth, Bakirkoy Dr Sadi Konuk Training & Res Hosp, Istanbul, Turkey
来源：
JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION | 2021年 / 71卷 / 02期
关键词：
Chronic hepatitis B; Tenofovir; partial response; Entecavir; combination therapy; DISOPROXIL FUMARATE; SAFETY;
D O I：
10.47391/JPMA.1135
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We report two treatment-na?ve cases, a 26-year-old female patient and a 59-year-old male patient who were followed up for chronic hepatitis B (CHB) at the department of Infectious Diseases and Clinical microbiology. A partial response subsequent to 12 months of Tenofovir Disoproksil (TDF) monotherapy presumably due to an antiviral-drug resistance was noted. A sustained viral response with TDF (245 mg) or Tenofovir Alafenamide (TAF, 25 mg) + Entecavir (ETV, 1 mg) combination therapy was observed after failure with TDF monotherapy. A combination therapy with TDF (245 mg) or TAF (25 mg) +ETV (1 mg) is efficacious in na?ve patients with a partial response to TDF monotherapy.
引用
收藏
页码：550 / 552
页数：3
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