Current state and future perspectives of supercritical fluid chromatography

For quite of time, supercritical fluid chromatography (SFC) is expected to make a big revolution in separation technologies. The technique is well known for developing fast and ultrafast high efficiency separation, improving the analytical method greenness. The evolution of SFC technologies (i.e., instrumentations, stationary phases) have shifted dramatically trends in SFC application from the chiral and pharmaceutical analysis toward new diverse application fields including drugs and bioactive compounds, metabolomics, environment, and food science analysis. Moreover, the applications have been greatly expanded toward the analysis of polar and very polar metabolites, resulting in certain successes. This review focuses on the most of SFC related studies during 2020-2021, covering the new development of SFC technologies, recent trends in application and method developments, and more importantly discusses the upcoming perspective regarding the art of supercritical fluid separation.(c) 2022 Published by Elsevier B.V.