Structural basis for the heme transfer reaction in heme uptake machinery from Corynebacteria

被引:4
|
作者
Muraki, Norifumi [1 ,2 ,3 ]
Kitatsuji, Chihiro [1 ]
Okamoto, Yasunori [1 ]
Uchida, Takeshi [4 ,5 ]
Ishimori, Koichiro [4 ,5 ]
Aono, Shigetoshi [1 ,2 ,3 ]
机构
[1] Natl Inst Nat Sci, Dept Creat Res, Exploratory Res Ctr Life & Living Syst ExCELLS, 5-1 Higashiyama,Myodaiji Cho, Okazaki, Aichi 4448787, Japan
[2] Natl Inst Nat Sci, Inst Mol Sci, 5-1 Higashiyama,Myodaiji Cho, Okazaki, Aichi 4448787, Japan
[3] Grad Univ Adv Studies, Dept Struct Mol Sci, 38 Nishogo Naka,Myodaiji Cho, Okazaki, Aichi 4448585, Japan
[4] Hokkaido Univ, Grad Sch Chem Sci & Engn, Sapporo, Hokkaido 0600810, Japan
[5] Hokkaido Univ, Dept Chem, Fac Sci, Sapporo, Hokkaido 0600810, Japan
关键词
IRON; PROTEIN; ACQUISITION; ISDC; HTAA; TRANSPORTERS; HEMOGLOBIN; DOMAIN; SYSTEM; NEAT;
D O I
10.1039/c9cc07369h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The crystal structures of the conserved region domains of HtaA and HtaB, which act as heme binding/transport proteins in the heme uptake machinery in Corynebacterium glutamicum, are determined for the first time. The molecular mechanism of heme transfer among these proteins is proposed based on the spectroscopic and structural analyses.
引用
收藏
页码:13864 / 13867
页数:4
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