Semiparametric inference for transformation models via empirical likelihood

Recent advances in the transformation model have made it possible to use this model for analyzing a variety of censored survival data. For inference on the regression parameters, there are semiparametric procedures based on the normal approximation. However, the accuracy of such procedures can be quite low when the censoring rate is heavy. In this paper, we apply an empirical likelihood ratio method and derive its limiting distribution via U-statistics. We obtain confidence regions for the regression parameters and compare the proposed method with the normal approximation based method in terms of coverage probability. The simulation results demonstrate that the proposed empirical likelihood method overcomes the under-coverage problem substantially and outperforms the normal approximation based method. The proposed method is illustrated with a real data example. Finally, our method can be applied to general U-statistic type estimating equations. (C) 2010 Elsevier Inc. All rights reserved.