Coeliac disease, epilepsy and cerebral calcifications

被引:63
|
作者
Gobbi, G [1 ]
机构
[1] Osped Maggiore Pizzardi, Unita Operat Neurol Infan, I-40133 Bologna, Italy
来源
BRAIN & DEVELOPMENT | 2005年 / 27卷 / 03期
关键词
coeliac disease; cerebral calcifications; occipital calcifications; epilepsy; occipital epilepsy;
D O I
10.1016/j.braindev.2004.05.003
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Coeliac disease, epilepsy and cerebral calcifications (CEC) syndrome is a rare clinical condition. One hundred and seventy-one patients have been reported in the literature. Patients are mostly from Italy, Spain, and Argentina, suggesting a geographically restricted condition. Epilepsy is more frequently characterized by occipital seizures. It may be benign or drug-resistant, sometime evolving into severe epileptic encephalopathy. Gluten free diet (GFD) efficacy seems to be inversely related to the duration of epilepsy and the young age of the patient. Patients with cerebral calcifications (CC) and coeliac disease (CD) without epilepsy are considered as having an incomplete form of CEC syndrome. Some patients with epilepsy and CC without CID are supposed to have a CEC syndrome with silent or latent CD. Whether CEC syndrome is a genetic condition, or whether epilepsy and/or CC are a consequence of an untreated CD is unknown yet. Since histopathological findings seem to be the expression of vascular calcifyied malformation, CEC syndrome may be considered a genetically determined entity, such as a type of Sturge-Weber-like phacomatosis. Moreover, CEC, as well as CD, is associated with HLA-DQ2 and HLA-DQ8 phenotype and genotype. The progressive growth and late occurrence of CC before beginning a GFD, the demonstration of anti-gliadin antibodies in the cerebro-spinal fluid and the association with HLA class II genes, suggest that an immune reaction originating from the jejunal mucosa, triggered by gliadin in gluten intolerance predisposed subjects (HLA phenotype) may be responsible for seizures and CC. Moreover, a long-lasting untreated CD folic acid deficiency may cause calcifications. Probably, CEC is considered a genetic, non-inherited, ethnically and geographically restricted syndrome associated with environmental factors. (c) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:189 / 200
页数:12
相关论文
共 50 条
  • [1] Epilepsy, cerebral calcifications and coeliac disease.
    Ferroir, JP
    Fenelon, G
    Billy, C
    Huon, R
    Herry, JP
    [J]. REVUE NEUROLOGIQUE, 1997, 153 (05) : 354 - 356
  • [2] The coeliac disease, cerebral calcifications and epilepsy syndrome
    Cuvellier, JC
    Vallee, L
    Nuyts, JP
    [J]. ARCHIVES DE PEDIATRIE, 1996, 3 (10): : 1013 - 1019
  • [3] Coeliac disease, epilepsy, cerebral calcifications: Incomplete forms
    Benna, P.
    Colonna, R.
    Montalenti, E.
    [J]. EPILEPSIA, 2006, 47 : 166 - 166
  • [4] Epilepsy cerebral calcifications and coeliac disease.: The importance of an early diagnosis
    Díaz, RM
    González-Rabelino, G
    Delfino, A
    [J]. REVISTA DE NEUROLOGIA, 2005, 40 (07) : 417 - 420
  • [5] Coeliac disease, epilepsy, and cerebral calcifications: association with TG6 autoantibodies
    Johnson, Alexandra M.
    Dale, Russell C.
    Wienholt, Louise
    Hadjivassiliou, Marios
    Aeschlimann, Daniel
    Lawson, John A.
    [J]. DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 2013, 55 (01): : 90 - 93
  • [6] Epilepsy, bilateral occipital calcifications and coeliac disease
    Giuffrida, S
    LePira, F
    Saponara, R
    LaSpina, V
    Milone, P
    Politi, G
    [J]. RIVISTA DI NEURORADIOLOGIA, 1996, 9 (03): : 345 - 348
  • [7] Epilepsy in coeliac disease: not just a matter of calcifications
    Licchetta, Laura
    Bisulli, Francesca
    Di Vito, Lidia
    La Morgia, Chiara
    Naldi, Ilaria
    Volta, Umberto
    Tinuper, Paolo
    [J]. NEUROLOGICAL SCIENCES, 2011, 32 (06) : 1069 - 1074
  • [8] Bilateral occipital calcifications, epilepsy and coeliac disease
    Kolníková, M
    Sykora, P
    Szabová, I
    Krajcírová, M
    Brozmanová, M
    [J]. CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE, 2000, 63 (04) : 240 - 243
  • [9] Epilepsy in coeliac disease: not just a matter of calcifications
    Laura Licchetta
    Francesca Bisulli
    Lidia Di Vito
    Chiara La Morgia
    Ilaria Naldi
    Umberto Volta
    Paolo Tinuper
    [J]. Neurological Sciences, 2011, 32 : 1069 - 1074
  • [10] Imaging of autoimmune phenomena in patients with coeliac disease epilepsy and cerebral calcifications syndrome.
    Gobbi, G
    Pavone, A
    Signore, A
    [J]. EPILEPSIA, 1999, 40 : 157 - 157