Determination of paroxetine levels in human plasma using gas chromatography with electron-capture detection

被引：29
|
作者：
Lai, CT [1 ]
Gordon, ES
Kennedy, SH
Bateson, AN
Coutts, RT
Baker, GB
机构：
[1] Univ Alberta, Neurochem Res Unit, Dept Psychiat, W Mackenzie Hlth Sci Ctr 1E744, Edmonton, AB T6G 2R7, Canada
[2] Univ Alberta, Dept Pharmacol, Edmonton, AB, Canada
[3] Univ Alberta, Div Neurosci, Edmonton, AB, Canada
[4] Ctr Addict & Mental Hlth, Toronto, ON, Canada
来源：
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2000年 / 749卷 / 02期
基金：
英国医学研究理事会;
关键词：
paroxetine; heptafluorobutyric anhydride;
D O I：
10.1016/S0378-4347(00)00389-3
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A simple, rapid and sensitive procedure using gas chromatography with electron-capture detection to measure paroxetine levels in human plasma has been developed. The analyte was extracted from plasma with ethyl acetate after basification of the plasma and then derivatized with heptafluorobutyric anhydride before gas chromatographic separation. The calibration curves were linear, with typical r(2) values >0.99. The assay was highly reproducible and gave peaks with excellent chromatographic properties. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：275 / 279
页数：5
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