Extrapulmonary small cell carcinoma of the bladder

被引:32
|
作者
Shahab, Nasir [1 ]
机构
[1] Univ Missouri, Dept Med, Sch Med, Ellis Fischel Canc Ctr, Columbia, MO 65203 USA
关键词
D O I
10.1053/j.seminoncol.2006.10.025
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Among the many sites for primary small cell cancer is the genitourinary system. The majority of cases have been observed in the bladder and prostate. Small cell carcinoma accounts for less than 1% of all bladder tumors. Definitive predisposing factors are unknown; however, small cell carcinoma of the bladder has been associated with cigarette smoking, long-standing cystitis, bladder calculus, and augmented cystoplasty. Contrary to the early theory of derivation from Kulchitsky cells, it is now believed that small cell carcinoma of the bladder originates from the totipotent stem cells present in the submucosa of the bladder wall. A number of chromosomal aberrations have been reported in small cell cancer of the bladder. There are no specific clinical features that differentiate these patients from transitional cell carcinoma of the bladder; however, some patients may have associated paraneoplastic conditions. Diagnosis is established by cystoscopic-assisted biopsy. Like small cell carcinoma of the lung, small cell carcinoma of the bladder has a propensity for early metastases. There is no standard therapy for small cell carcinoma of the bladder and the prognosis is poor; however, patients treated with cisplatin-based chemotherapy regimens seem to have a better prognosis. © 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:15 / 21
页数:7
相关论文
共 50 条
  • [1] Extrapulmonary small cell carcinoma
    Galanis, E
    Frytak, S
    Lloyd, RV
    [J]. CANCER, 1997, 79 (09) : 1729 - 1736
  • [2] Extrapulmonary small cell carcinoma
    van der Heijden, HFM
    Heijdra, YF
    [J]. SOUTHERN MEDICAL JOURNAL, 2005, 98 (03) : 345 - 349
  • [3] The pathology of extrapulmonary small cell carcinoma
    Frazier, Shellaine R.
    Kaplan, Paul A.
    Loy, Timothy S.
    [J]. SEMINARS IN ONCOLOGY, 2007, 34 (01) : 30 - 38
  • [4] Extrapulmonary small cell carcinoma - Introduction
    Shahab, Nasir
    Mirza, Irfan A.
    Doll, Donald
    [J]. SEMINARS IN ONCOLOGY, 2007, 34 (01) : 1 - 2
  • [5] EXTRAPULMONARY SMALL CELL-CARCINOMA
    WURTZ, K
    GUTHRIE, TH
    [J]. CLINICAL RESEARCH, 1986, 34 (01): : A201 - A201
  • [6] Nonesophagical extrapulmonary small cell carcinoma
    Valenzuela, JC
    Reina, JJ
    Rueda, A
    Valladares, M
    Contreras, JA
    Calvo, E
    Iglesias, L
    Noguer, M
    Pastor, P
    Ruiz, M
    Moreno, JA
    [J]. EUROPEAN JOURNAL OF CANCER, 1995, 31A : 96 - 96
  • [7] EXTRAPULMONARY SMALL-CELL CARCINOMA
    LEDERMANN, JA
    [J]. POSTGRADUATE MEDICAL JOURNAL, 1992, 68 (796) : 79 - 81
  • [8] Extrapulmonary Small Cell Carcinoma of the Rectum
    Yugang Wu
    Qing Wang
    Liang Wang
    Xiaozhou He
    [J]. Journal of Gastrointestinal Cancer, 2012, 43 (Suppl 1) : 258 - 261
  • [9] Imaging features of extrapulmonary small cell carcinoma
    Joyce, E. A.
    Kavanagh, J.
    Sheehy, N.
    Beddy, P.
    O'Keeffe, S. A.
    [J]. CLINICAL RADIOLOGY, 2013, 68 (09) : 953 - 961
  • [10] Extrapulmonary small cell carcinoma in breast and prostate
    Juan Quirós Rivero
    Julia Luisa Muñoz García
    Joaquín José Cabrera Rodríguez
    José Antonio González Ferreira
    Pilar Samper Ots
    Yésika Ríos Kavadoy
    [J]. Clinical and Translational Oncology, 2009, 11 : 698 - 700