Synthesis and cytotoxic evaluation of novel simplified plinabulin-quinoline derivatives

被引：6
|
作者：
Tham, Pham T. [1 ]
Chinh, Pham T. [2 ]
Tuyen, Nguyen, V [3 ]
Bang, Duong N. [2 ]
Van, Dinh T. [2 ,4 ]
Kien, Vu T. [2 ]
Thanh, Hoang T. [2 ]
Quynh, Duong H. [2 ,3 ]
Cuong, Vu D. [2 ,5 ]
Thanh, Nguyen H. [2 ,3 ]
Perez-Encabo, Alfonso [6 ]
机构：
[1] Hanoi Univ Ind, Hanoi, Vietnam
[2] Thai Nguyen Univ Sci, Tan Thinh 24000, Thai Nguyen, Vietnam
[3] Vietnam Acad Sci & Technol, Inst Chem, 18 Hoang Quoc Viet, Hanoi, Vietnam
[4] Thai Nguyen Univ Educ, Luong Ngoc Quyen, Thai Nguyen, Vietnam
[5] Viet Tri Univ Ind, Viet Tri, Phu Tho, Vietnam
[6] Univ Valladolid, Fac Ciencias, IU CINQUIMA Quim Organ, E-47011 Valladolid, Spain
来源：
MENDELEEV COMMUNICATIONS | 2021年 / 31卷 / 02期
关键词：
plinabulin; quinoline; piperazine-2,5-diones; anticancer; cytotoxicity; IMPROVES; AGENTS;
D O I：
10.1016/j.mencom.2021.03.022
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of new plinabulin-quinoline derivatives and their simplified analogues was obtained from N,N'-diacetyl-2,5-diketopiperazines utilizing its aldol condensation with benzaldehydes. One compound showed strong activity related to three (KB, HepG2 and Lu) cancer cell lines while two other compounds demonstrated high potencies against breast carcinoma cell line (MCF-7).
引用
收藏
页码：213 / 215
页数：3
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