Organocatalytic synthesis of axially chiral atropisomers

被引：98
|
作者：
Renzi, P. [1 ]
机构：
[1] Univ Regensburg, Inst Organ Chem, Univ Str 31, D-93053 Regensburg, Germany
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 21期
基金：
欧洲研究理事会;
关键词：
DYNAMIC KINETIC RESOLUTION; ENANTIOSELECTIVE SYNTHESIS; ATROPOSELECTIVE SYNTHESIS; ASYMMETRIC-SYNTHESIS; BIARYL COMPOUNDS; BROMINATION; ARYLATION; ACIDS;
D O I：
10.1039/c7ob00908a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This Review summarises the recent progress made in the organocatalytic synthesis of atropisomeric compounds. Methodologies based on dynamic kinetic resolution and direct access to BINOL-like biaryls are described. A particular emphasis is given to reaction mechanisms and to the development of strategies to obtain stable products by increasing the barrier to atropisomer interconversion during the reaction.
引用
收藏
页码：4506 / 4516
页数：11
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