Commentary - CRISPR-based techniques: Cas9, Cas13 and their applications in the era of COVID-19

被引:4
|
作者
Zaami, S. [1 ]
Piergentili, R. [2 ]
Marinelli, E. [1 ]
Vergallo, G. Montanari [1 ]
机构
[1] Sapienza Univ Rome, Dept Anat Histol Forens & Orthoped Sci, Rome, Italy
[2] Italian Natl Res Council, Inst Mol Biol & Pathol, Rome, Italy
关键词
CRISPR/Cas9-Cas13; Germline gene editing; Enhancement; Human embryo research; Sars-CoV-2; GENOME; TECHNOLOGY; SARS-COV-2;
D O I
10.26355/eurrev_202102_24886
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)/Cas9 (CRISPR-associated protein 9) system enables scientists to edit diverse genome types with relative ease, with the aim - in the near future - to prevent future human beings from developing genetic diseases. The new opportunities arising from the system are broad-ranging and revolutionary, but such prospects have also been the cause for alarm throughout the international scientific community. The authors have laid out a review of the trials carried out so far in terms of genome editing, for the ultimate purpose of weighing implications and criticisms. We feel that possible valuable alternatives, such as induced pluripotent stem cells should not be overlooked.
引用
收藏
页码:1752 / 1761
页数:10
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