Laminarin promotes anti-cancer immunity by the maturation of dendritic cells

被引:49
|
作者
Song, Kyeongeun [1 ,2 ]
Xu, Li [1 ]
Zhang, Wei [1 ]
Cai, Yun [1 ]
Jang, Bian [1 ,2 ,3 ,4 ,5 ]
Oh, Junghwan [2 ,3 ,4 ,5 ]
Jin, Jun-O [1 ]
机构
[1] Fudan Univ, Shanghai Med Coll, Shanghai Publ Hlth Clin Ctr, Shanghai 201508, Peoples R China
[2] Pukyong Natl Univ, Marine Integrated Bion Res Ctr, Busan 48513, South Korea
[3] Pukyong Natl Univ, Dept Biomed Engn, Busan 48513, South Korea
[4] Pukyong Natl Univ, Ctr Marine Integrated Biomed Technol Plus BK21, Busan 48513, South Korea
[5] Pukyong Natl Univ, Interdisciplinary Program Biomed Mech & Elect Eng, Busan 48513, South Korea
基金
中国国家自然科学基金;
关键词
laminarin; adjuvant; anti-cancer; dendritic cell maturation; cytotoxic lymphocyte activation; SCAVENGER RECEPTOR; CANCER-IMMUNOTHERAPY; GROWTH-PERFORMANCE; FUCOIDAN; TUMOR; MACROPHAGES; POLYSACCHARIDES; ADJUVANT; VACCINES; DECTIN-1;
D O I
10.18632/oncotarget.16170
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
This research evaluates the effects of laminarin on the maturation of dendritic cells and on the in vivo activation of anti-cancer immunity. In vivo treatment of C56BL/6 mice with laminarin increased the expression levels of co-stimulatory molecules and the production of pro-inflammatory cytokines in spleen dendritic cells. Laminarin enhanced ovalbumin antigen presentation in spleen dendritic cells and promoted the proliferation of OT-I and OT-II T cells. Laminarin also induced the maturation of dendritic cells in tumor-draining lymph nodes and protected interferon-gamma and tumor necrosis factor-alpha and proliferation of OT-I and OT-II T cells in tumors. The combination treatment of laminarin and ovalbumin inhibited B16-ovallbumin melanoma tumor growth and its liver metastasis by antigen-specific immune activation, including cytotoxic T lymphocyte activation and interferon-gamma production. Thus, these data demonstrated the potential of laminarin as a new and useful immune stimulatory molecule for use in cancer immunotherapy.
引用
收藏
页码:38554 / 38567
页数:14
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