Association between Aortic Valve Calcification Progression and Coronary Atherosclerotic Plaque Volume Progression in the PARADIGM Registry

被引：13

作者：

Lee, Sang-Eun ^{[1
,2
]}

Sung, Ji Min ^{[2
,3
]}

Andreini, Daniele ^{[4
]}

Al-Mallah, Mouaz H. ^{[5
]}

Budoff, Matthew J. ^{[6
]}

Cademartiri, Filippo ^{[7
]}

Chinnaiyan, Kavitha ^{[8
]}

Choi, Jung Hyun ^{[9
]}

Chun, Eun Ju ^{[10
]}

Conte, Edoardo ^{[4
]}

Gottlieb, Ilan ^{[11
]}

Hadamitzky, Martin ^{[12
]}

Kim, Yong Jin ^{[13
]}

Lee, Byoung Kwon ^{[14
]}

Leipsic, Jonathon A. ^{[15
]}

Maffei, Erica ^{[16
]}

Marques, Hugo ^{[17
]}

Goncalves, Pedro de Araujo ^{[17
]}

Pontone, Gianluca ^{[4
]}

Shin, Sanghoon ^{[3
]}

Stone, Peter H. ^{[18
]}

Samady, Habib ^{[19
]}

Virmani, Renu ^{[20
]}

Narula, Jagat ^{[21
]}

Berman, Daniel S. ^{[22
]}

Shaw, Leslee J. ^{[23
]}

Bax, Jeroen J. ^{[24
]}

Lin, Fay Y. ^{[23
]}

Min, James K. ^{[23
]}

Chang, Hyuk-Jae ^{[2
,3
]}

机构：

[1] Ewha Womans Univ, Coll Med, Seoul Hosp, Dept Internal Med,Div Cardiol, Seoul, South Korea

[2] Yonsei Univ, Yonsei Univ Hlth Syst, Coll Med, Yonsei Cedars Sinai Integrat Cardiovasc Imaging R, Seoul, South Korea

[3] Yonsei Univ, Coll Med, Yonsei Univ Hlth Syst, Severance Cardiovasc Hosp,Div Cardiol, 30-1 Yonsei Ro, Seoul 03722, South Korea

[4] IRCCS, Ctr Cardiol Monzino, Milan, Italy

[5] Houston Methodist Hosp, Houston Methodist DeBakey Heart & Vasc Ctr, Houston, TX 77030 USA

[6] Los Angeles Biomed Res Inst, Dept Med, Torrance, CA USA

[7] SDN IRCCS, Cardiovasc Imaging Unit, Naples, Italy

[8] William Beaumont Hosp, Dept Cardiol, Royal Oak, MI 48072 USA

[9] Pusan Univ Hosp, Busan, South Korea

[10] Seoul Natl Univ, Bundang Hosp, Seongnam, South Korea

[11] Casa Saude Sao Jose, Dept Radiol, Rio De Janeiro, Brazil

[12] German Heart Ctr Munich, Dept Radiol & Nucl Med, Munich, Germany

[13] Seoul Natl Univ, Cardiovasc Ctr, Seoul Natl Univ Hosp, Coll Med,Dept Internal Med, Seoul, South Korea

[14] Yonsei Univ, Gangnam Severance Hosp, Coll Med, Seoul, South Korea

[15] Univ British Columbia, Dept Med & Radiol, Vancouver, BC, Canada

[16] Area Vasta 1 ASUR Marche, Dept Radiol, Urbino, Italy

[17] Hosp Luz, Unit Cardiovasc Imaging, UNICA, Lisbon, Portugal

[18] Brigham & Womens Hosp, Div Cardiovasc Med, 75 Francis St, Boston, MA 02115 USA

[19] Emory Univ, Sch Med, Div Cardiol, Atlanta, GA 30322 USA

[20] CVPath Inst, Dept Pathol, Gaithersburg, MD USA

[21] Icahn Sch Med Mt Sinai, New York, NY 10029 USA

[22] Cedars Sinai Med Ctr, Dept Imaging & Med, Los Angeles, CA 90048 USA

[23] New York Presbyterian Hosp, Dept Radiol, New York, NY USA

[24] Leiden Univ, Dept Cardiol, Med Ctr, Leiden, Netherlands

来源：

RADIOLOGY | 2021年 / 300卷 / 01期

关键词：

COMPUTED TOMOGRAPHIC ANGIOGRAPHY; SCCT GUIDELINES; QUANTIFICATION; CALCIUM; DISEASE; SOCIETY; IMPACT; STATINS; EVENTS;

D O I：

10.1148/radiol.2021202630

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Background: Aortic valve calcification (AVC) is a key feature of aortic stenosis, and patients with aortic stenosis often have coronary-artery disease. Therefore, proving the association between the progression of AVC and coronary atherosclerosis could improve follow-up and treatment strategies. Purpose: To explore the association between the progression of AVC and the progression of total and plaque volume composition from a large multicenter registry of serial coronary CT angiographic examinations. Materials and Methods: A prospective multinational registry (PARADIGM) of consecutive participants who underwent serial coronary CT angiography at intervals of every 2 years or more was performed (January 2003-December 2015). AVC and the total and plaque volume composition at baseline and follow-up angiography were quantitatively analyzed. Plaque volumes were normalized by using the mean total analyzed vessel length of the study population. Multivariable linear mixed-effects models were constructed. Results: Overall, 594 participants (mean age. standard deviation, 62 years. 10; 330 men) were included (mean interval between baseline and follow-up angiography, 3.9 years. 1.5). At baseline, the AVC score was 31 Agatston units. 117, and the normalized total plaque volume at baseline was 122 mm(3)+/- 219. After adjustment for age, sex, clinical risk factors, and medication use, AVC was independently associated with total plaque volume (standardized. = 0.24; 95% CI: 0.16, 0.32; P..001) and both calcified (beta = 0.26; 95% CI: 0.18, 0.34; P<.001) and noncalcified (beta = 0.17; 95% CI: 0.08, 0.25; P..001) plaque volumes at baseline. The progression of AVC was associated with the progression of total plaque volume (beta = 0.13; 95% CI: 0.03, 0.22; P =.01), driven solely by calcified plaque volume (beta = 0.24; 95% CI: 0.14, 0.34; P<.001) but not noncalcified plaque volumes (beta =.0.06; 95% CI:.0.14, 0.03; P =.17). Conclusion: The overall burden of coronary atherosclerosis was associated with aortic valve calcification at baseline. However, the progression of aortic valve calcification was associated with only the progression of calcified plaque volume but not with the -progression of noncalcified plaque volume. (C) RSNA. 2021

引用

页码：79 / 86

页数：8

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