Dicationic Ruthenium(II)-Arene-Curcumin Complexes Containing Methylated 1,3,5-Triaza-7-phosphaadamantane: Synthesis, Structure, and Cytotoxicity

被引：23
|
作者：
Pettinari, Riccardo [1 ]
Condello, Francesca [1 ]
Marchetti, Fabio [2 ]
Pettinari, Claudio [1 ]
Smolenski, Piotr [3 ]
Riedel, Tina [4 ]
Scopelliti, Rosario [4 ]
Dyson, Paul J. [4 ]
机构：
[1] Univ Camerino, Sch Pharm, Via S Agostino 1, I-62032 Camerino, MC, Italy
[2] Univ Camerino, Sch Sch Sci & Technol, Via S Agostino 1, I-62032 Camerino, MC, Italy
[3] Univ Wroclaw, Fac Chem, Ul F Joliot Curie 14, PL-50383 Wroclaw, Poland
[4] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland
来源：
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2017年 / 22期
基金：
瑞士国家科学基金会;
关键词：
Curcumin; Bisdemethoxycurcumin; Arene ligands; Ruthenium; Cytotoxicity; Antitumor agents; ANTIINFLAMMATORY AGENT; ANTICANCER ACTIVITY; ANTITUMOR-ACTIVITY; METAL-COMPLEXES; IN-VITRO; CURCUMIN; THERAPY; DERIVATIVES; INDUCTION; DRUGS;
D O I：
10.1002/ejic.201700183
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Dicationic ruthenium(II)-p-cymene complexes containing curcumin ligands (curcH = curcumin, bdcurcH = bisdemethoxycurcumin) and ionic N-methyl-1,3,5-triaza-7-phosphaadamantane [PTA-Me]X (X = BF4 or I) have been synthesized and fully characterized for the first time. The solid-state structure of [Ru(p-cym)(curc)(PTA-Me)][SO3CF3][BF4] has also been determined by single-crystal X-ray diffraction. Modest antiproliferative activities of the complexes were observed against cis-platin-sensitive and cisplatin-resistant human ovarian carcinoma cells (A2780 and A2780cisR, respectively) and nontumorigenic human embryonic kidney (HEK293) cells.
引用
收藏
页码：2905 / 2910
页数：6
相关论文
共 50 条
  • [1] Ruthenium Complexes Containing 2,2′-Bipyridine and 1,3,5-Triaza-7-phosphaadamantane
    Scalambra, Franco
    Serrano-Ruiz, Manuel
    Nahim-Granados, Samira
    Romerosa, Antonio
    [J]. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2016, (10) : 1528 - 1540
  • [2] Thermal and photochemical reactivity of tetraamineruthenium complexes containing 1,3,5-triaza-7-phosphaadamantane as a ligand
    Frugeri, PM
    Vasconcellos, LCG
    Mazzetto, SE
    Franco, DW
    [J]. NEW JOURNAL OF CHEMISTRY, 1997, 21 (03) : 349 - 354
  • [3] Synthesis and structures of nickel and palladium salicylaldiminato 1,3,5-triaza-7-phosphaadamantane (PTA) complexes
    Darensbourg, DJ
    Ortiz, CG
    Yarbrough, JC
    [J]. INORGANIC CHEMISTRY, 2003, 42 (21) : 6915 - 6922
  • [4] Synthesis of water-soluble ruthenium clusters by reaction with PTA (1,3,5-triaza-7-phosphaadamantane)
    Mager, Nathalie
    Robeyns, Koen
    Hermans, Sophie
    [J]. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2015, 794 : 48 - 58
  • [5] INOR 942-Synthesis, structure and complexes of triiminomethylphosphine and trisubstituted 1,3,5-triaza-7-phosphaadamantane ligands
    Huang, Rongcai
    Frost, Brian J.
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, 235
  • [6] trans-diiodobis(1,3,5-triaza-7-phosphaadamantane)platinum(II)
    Otto, S
    Roodt, A
    [J]. ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 2001, 57 : 540 - 541
  • [7] Easy synthesis and water solubility of ruthenium complexes containing PPh3, mTPPMS, PTA and mPTA, (mTPPMS = meta-triphenyphosphine monosulfonate, PTA=1,3,5-triaza-7-phosphaadamantane, mPTA = N-methyl-1,3,5-triaza-7-phosphaadamantane)
    Serrano-Ruiz, Manuel
    Lorenzo-Luis, Pablo
    Romerosa, Antonio
    [J]. INORGANICA CHIMICA ACTA, 2017, 455 : 528 - 534
  • [8] MONOPHOSPHAUROTROPIN (1,3,5-TRIAZA-7-PHOSPHAADAMANTANE) AND SOME DERIVATIVES
    FLUCK, E
    FORSTER, JE
    [J]. CHEMIKER-ZEITUNG, 1975, 99 (05): : 246 - 247
  • [9] 1,3,5-TRIAZA-7-PHOSPHAADAMANTANE (MONOPHOSPHA-UROTROPINE)
    FLUCK, E
    FORSTER, JE
    WEIDLEIN, J
    HADICKE, E
    [J]. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 1977, 32 (05): : 499 - 506
  • [10] Study of the biological activity of photoactive bipyridyl-Ru(II) complexes containing 1,3,5-triaza-7-phosphaadamantane (PTA)
    del Pino, Jose Manuel Veiga
    Scalambra, Franco
    Bermejo-Casadesus, Cristina
    Massaguer, Anna
    Garcia-Maroto, Federico
    Romerosa, Antonio
    [J]. JOURNAL OF INORGANIC BIOCHEMISTRY, 2023, 246
12345