Free volume and dynamics in a lipid bilayer

被引：8

作者：

Gironi, Beatrice ^{[1
]}

Lapini, Andrea ^{[2
,3
]}

Ragnoni, Elena ^{[3
]}

Calvagna, Chiara ^{[3
]}

Paolantoni, Marco ^{[1
]}

Morresi, Assunta ^{[1
]}

Sassi, Paola ^{[1
,4
]}

机构：

[1] Univ Perugia, Dipartimento Chim Biol & Biotecnol, Via Elce Sotto 8, I-06123 Perugia, Italy

[2] Ist Nazl Ric Metrol INRIM, Str Cacce 91, I-10135 Turin, Italy

[3] Univ Firenze, European Lab Non Linear Spect LENS, Via Nello Carrara 1, I-50019 Florence, Italy

[4] Univ Perugia, CEMIN, Via Elce Sotto 8, I-06123 Perugia, Italy

来源：

PHYSICAL CHEMISTRY CHEMICAL PHYSICS | 2019年 / 21卷 / 41期

关键词：

ULTRAFAST STRUCTURAL DYNAMICS; LATERAL DIFFUSION; CELL-MEMBRANES; CHOLESTEROL; SPECTROSCOPY; DIMETHYLSULFOXIDE; MONOLAYERS; VESICLE; MODEL; DPPC;

D O I：

10.1039/c9cp03451j

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The lateral diffusion of lipids and of small molecules inside a membrane is strictly related to the arrangement of acyl chains and to their mobility. In this study, we use FTIR and time resolved 2D-IR spectroscopic techniques to characterize the structure and dynamics of the hydrophobic region of palmitoyl-oleylphosphatidylcholine/cholesterol vesicles dispersed in water/dimethylsulfoxide solutions. By means of a non-polar probe, hexacarbonyl tungsten, we monitor the distribution of free volumes inside the bilayer and the conformational dynamics of hydrophobic tails in relation to the different compositions of the membrane or the different compositions of the solvent. Despite the important structural changes induced by the presence of DMSO in the solvating medium, the picosecond dynamics of the membrane is preserved under the different conditions.

引用

页码：23169 / 23178

页数：10

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