Metal-free catalytic enantioselective silylation of aromatic aldehydes in water

被引：8
|
作者：
Huo, Yuwen [1 ]
Shen, Panpan [1 ]
Duan, Wenzeng [2 ]
Chen, Zhen [3 ]
Song, Chun [1 ]
Ma, Yudao [1 ]
机构：
[1] Shandong Univ, Dept Chem, Jinan 250100, Shandong, Peoples R China
[2] Liaocheng Univ, Sch Chem & Chem Engn, Liaocheng 252000, Peoples R China
[3] Hebei Normal Univ Nationalities, Sch Chem & Chem Engn, Higher Educ Pk, Chengde 0670000, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2018年 / 29卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Silylation; Asymmetric catalysis; N-Heterocyclic carbene; 2.2]Paracyclophane; alpha-Hydroxysilane; N-HETEROCYCLIC CARBENE; NUCLEOPHILIC SILICON; ASYMMETRIC-SYNTHESIS; CONJUGATE ADDITIONS; ALLYLIC ALKYLATION; KINETIC RESOLUTION; ORGANIC-SYNTHESIS; BOND FORMATION; LIGANDS; HYDROGENATION;
D O I：
10.1016/j.cclet.2017.12.005
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An environmentally friendly and transition metal-free method for the preparation of chiral alpha-hydroxysilanes was developed. Enantioselective addition of a silicon nucleophile to aromatic aldehydes in water was achieved by using a new hydroxyl-functionalized chiral carbene as catalyst, affording the corresponding products in good yields and moderate enantioselectivities. (C) 2017 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1359 / 1362
页数：4
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