Gender-related differences in aneurysmal subarachnoid hemorrhage

被引:158
|
作者
Kongable, GL
Lanzino, G
Germanson, TP
Truskowski, LL
Alves, WM
Torner, JC
Kassell, NF
Spetzler, RF
Zabramski, J
Culicchia, F
Carter, LP
Feinberg, W
Urbina, C
Lopez, L
Brown, D
Tallman, D
Selman, WR
Harrington, F
Warf, B
Barnett, GJ
Little, J
Palmer, J
Campbell, RL
Shapiro, S
Farlow, M
Kay, S
Horner, T
Leipzig, T
Redelman, K
Muizelaar, JP
Turner, R
Kamesh, W
Bouma, G
Reyes, RD
Rosenbaum, D
Klonowski, E
Mohr, G
Bojanowski, M
Bernier, G
Duquette, P
LaPlante, P
Murali, R
Crisafulli, C
Merkel, C
Rosner, MK
Mahaley, MS
Aronin, PA
Morawetz, RB
Rosner, S
BrockSillers, RN
机构
[1] UNIV VIRGINIA,HLTH SCI CTR,VIRGINIA NEUROL INST,CHARLOTTESVILLE,VA 22908
[2] UNIV IOWA,DEPT PREVENT MED & ENVIRONM HLTH,IOWA CITY,IA 52242
[3] UNIV ARIZONA,BARROW NEUROL INST,PHOENIX,AZ
[4] UNIV ARIZONA,BARROW NEUROL INST,TUCSON,AZ 85721
[5] CASE WESTERN RESERVE UNIV,CLEVELAND,OH 44106
[6] CLEVELAND CLIN,CLEVELAND,OH 44106
[7] INDIANA UNIV,INDIANAPOLIS,IN 46204
[8] INDIANAPOLIS NEUROSURG GRP,INDIANAPOLIS,IN
[9] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,RICHMOND,VA 23298
[10] MONTEFIORE HOSP,NEW YORK,NY
[11] UNIV MONTREAL,NOTRE DAME HOSP,MONTREAL,PQ H3C 3J7,CANADA
[12] ST VINCENTS HOSP,NEW YORK,NY
[13] UNIV ALABAMA,BIRMINGHAM,AL
[14] UNIV CALIF SAN DIEGO,SAN DIEGO,CA 92103
[15] UNIV KENTUCKY,LEXINGTON,KY 40506
[16] UNIV MARYLAND,COLLEGE PK,MD 20742
[17] UNIV N CAROLINA,CHAPEL HILL,NC 27515
[18] UNIV PENN,PHILADELPHIA,PA 19104
[19] UNIV TEXAS,GALVESTON,TX
[20] UNIV UTAH,SALT LAKE CITY,UT 84112
[21] UNIV WASHINGTON,SEATTLE,WA 98195
[22] WASHINGTON UNIV,ST LOUIS,MO 63130
[23] UNIV WESTERN ONTARIO,LONDON,ON N6A 3K7,CANADA
[24] UNIV TEXAS,HOUSTON,TX
[25] GEORGETOWN UNIV,WASHINGTON,DC 20057
[26] UNIV CHICAGO,CHICAGO,IL 60637
关键词
aneurysm; subarachnoid hemorrhage; gender;
D O I
10.3171/jns.1996.84.1.0043
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Female gender is a recognized risk factor for the occurrence of aneurysmal subarachnoid hemorrhage. In the present study the authors analyzed differences in admission characteristics and outcome between 578 women (64%) and 328 men (36%) who were enrolled in a recently completed clinical trial. The female-to-male ratio was nearly 2:1. The women in the study were older than the men (mean age 51.4 years vs. 47.3 years, respectively, p < 0.001). Female patients harbored aneurysms of the internal carotid artery more frequently than male patients (36.8% vs. 18.0%, p < 0.001) and more often had multiple aneurysms (32.4% vs. 17.6%, p < 0.001). On the other hand, anterior cerebral artery aneurysms were more commonly encountered in men (46.1% in men vs. 26.646 in women, p ( 0.001). Other baseline prognostic factors were balanced between the gender groups. Surgery was performed equally in both sexes (98%), although the time to operation was shorter for women (mean 3.6 days for women vs. 5.3 days for men, p = 0.0002). In the placebo group, the occurrence of vasospasm was not statistically different between the two groups. Primary causes of death and disability were the same, and favorable outcome rates at 3 months were not statistically different between the genders (69.7% for women vs. 73.4% for men, p = 0.243). The odds of a favorable outcome in women versus one in men were not statistically significant either before or after adjustment for age. These observations lead the authors to suggest that although women are older and harbor more aneurysms, the 3-month outcome for women and men who experience aneurysmal subarachnoid hemorrhage is the same.
引用
收藏
页码:43 / 48
页数:6
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