Genetic analyses of the brain-derived neurotrophic factor (BDNF) gene in autism

被引：68
|
作者：
Nishimura, Katsuhiko
Nakamura, Kazuhiko [1 ]
Anitha, A.
Yamada, Kazuo
Tsujii, Masatsugu
Iwayama, Yoshimi
Hattori, Eiji
Toyota, Tomoko
Takei, Nori
Miyachi, Taishi
Iwata, Yasuhide
Suzuki, Katsuaki
Matsuzaki, Hideo
Kawai, Masayoshi
Sekine, Yoshimoto
Tsuchiya, Kenji
Sugihara, Gen-ichi
Suda, Shiro
Ouchi, Yasuomi
Sugiyama, Toshiro
Yoshikawa, Takeo
Mori, Norio
机构：
[1] Hamamatsu Univ Sch Med, Dept Psychiat & Neurol, Hamamatsu, Shizuoka 43131, Japan
[2] RIKEN, Brain Sci Inst, Lab Mol Psychiat, Saitama, Japan
[3] Chukyo Univ, Fac Sociol, Toyota, Aichi, Japan
[4] Hamamatsu Univ Sch Med, Osaka Hamamatsu Joint Res Ctr Child Mental Dev, Hamamatsu, Shizuoka 43131, Japan
[5] Osaka Univ, Osaka Hamamatsu Joint Res Ctr Child Mental Dev, Grad Sch Med, Suita, Osaka 565, Japan
[6] Hamamatsu Med Ctr, Positron Med Ctr, Hamamatsu, Shizuoka, Japan
[7] Aichi Childrens Hlth & Med Ctr, Aichi, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 356卷 / 01期
关键词：
autism; brain-derived neurotrophic factor; serotonin transporter; a trios-based association; peripheral blood lymphocytes;
D O I：
10.1016/j.bbrc.2007.02.135
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Autism is a severe neurodevelopmental disorder defined by social and communication deficits and ritualistic-repetitive behaviors that are detectable in early childhood. Brain-derived neurotrophic factor (BDNF) plays a critical role in the pathogenesis of autism. In this study, we examined the SNP- and haplotypic-association of BDNF with autism in a trios-based association study (the Autism Genetic Resource Exchange). We also examined the expression of BDNF mRNA in the peripheral blood lymphocytes of drug-naive autism patients and control subjects. In the TDT of autism trios, the SNP haplotype combinations showed significant associations in the autism group. BDNF expression in the drug-naive autistic group was found to be significantly higher than in the control group. We suggest that BDNF has a possible role in the pathogenesis of autism through its neurotrophic effects on the serotonergic system. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：200 / 206
页数：7
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