Increased Risk of Colorectal Cancer in Patients With Multiple Serrated Polyps and Their First-Degree Relatives

被引：19

作者：

Egoavil, Cecilia ^{[1
]}

Juarez, Miriam ^{[1
]}

Guarinos, Carla ^{[1
]}

Rodriguez-Soler, Maria ^{[2
]}

Hernandez-Illan, Eva ^{[1
]}

Alenda, Cristina ^{[3
]}

Paya, Artemio ^{[3
]}

Castillejo, Adela ^{[5
]}

Serradesanferm, Anna ^{[6
]}

Bujanda, Luis ^{[7
]}

Fernandez-Banares, Fernando ^{[8
]}

Cubiella, Joaquin ^{[9
]}

De-Castro, Luisa ^{[10
]}

Guerra, Ana ^{[11
]}

Aguirre, Elena ^{[12
]}

Herreros-de-Tejada, Alberto ^{[13
]}

Bessa, Xavier ^{[14
]}

Herraiz, Maite ^{[15
]}

Marin-Gabriel, Jose-Carlos ^{[16
]}

Balmana, Judith ^{[17
]}

Pinol, Virginia ^{[18
]}

Rodriguez Moranta, Francisco ^{[19
]}

Nicolas-Perez, David ^{[20
]}

Cuatrecasas, Miriam ^{[21
]}

Balaguer, Francesc ^{[6
]}

Castells, Antoni ^{[6
]}

Soto, Jose-Luis ^{[5
]}

Zapater, Pedro ^{[4
]}

Jover, Rodrigo ^{[1
,2
]}

机构：

[1] Alicante Univ Gen Hosp, Res Lab, Alicante, Spain

[2] Alicante Univ Gen Hosp, Serv Digest Med, Alicante, Spain

[3] Alicante Univ Gen Hosp, Dept Pathol, Alicante, Spain

[4] Alicante Univ Gen Hosp, Clin Pharmacol Dept, Alicante, Spain

[5] Elche Univ Gen Hosp, Mol Genet Lab, Alicante Inst Hlth & Biomed Res, Inst Invest Sanitaria & Biomed Alicante, Alicante, Spain

[6] Hosp Clin Barcelona, CIBERehd, Inst Malaties Digest & Metab, Barcelona, Spain

[7] Univ Basque Country, Hosp Donostia, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Gastroenterol Dept, San Sebastian, Spain

[8] Hosp Mutua Terrassa, Gastroenterol Dept, Terrassa, Spain

[9] Complexo Hosp Univ Ourense, Gastroenterol Dept, Orense, Spain

[10] Complexo Hosp Vigo, Gastroenterol Dept, Vigo, Spain

[11] Complejo Hosp Navarra, Dept Gastroenterol, Pamplona, Spain

[12] Hosp Arnau Vilanova, Dept Oncol, Lleida, Spain

[13] Hosp Puerta de Hierro, Gastroenterol Dept, Madrid, Spain

[14] Hosp del Mar, Med Res Inst, Dept Gastroenterol, Barcelona, Spain

[15] Clin Univ Navarra, Gastroenterol Dept, Pamplona, Spain

[16] Hosp 12 Octubre, Dept Gastroenterol, Madrid, Spain

[17] Hosp Valle De Hebron, Oncol Dept, Barcelona, Spain

[18] Hosp Univ Dr Josep Trueta, Gastroenterol Dept, Girona, Spain

[19] Hosp Bellvitge Princeps Espanya, Gastroenterol Dept, Barcelona, Spain

[20] Hosp Univ Canarias, Gastroenterol Dept, Santa Cruz De Tenerife, Spain

[21] Hosp Clin Barcelona, Dept Pathol, Barcelona, Spain

来源：

GASTROENTEROLOGY | 2017年 / 153卷 / 01期

关键词：

Colon Cancer; SPS; Surveillance; Cancer Risk; HYPERPLASTIC POLYPOSIS; PREVALENCE; NEOPLASIA; SERIES;

D O I：

10.1053/j.gastro.2017.04.003

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

BACKGROUND & AIMS: We investigated whether patients with multiple serrated polyps, but not meeting the World Health Organization criteria for serrated polyposis syndrome, and their relatives have similar risks for colorectal cancer (CRC) as those diagnosed with serrated polyposis. METHODS: We collected data from patients with more than 10 colonic polyps, recruited in 2008-2009 from 24 hospitals in Spain for a study of causes of multiple colonic polyps. We analyzed data from 53 patients who met the criteria for serrated polyposis and 145 patients who did not meet these criteria, but who had more than 10 polyps throughout the colon, of which more than 50% were serrated. We calculated age-and sex-adjusted standardized incidence ratios (SIRs) for CRC in both groups, as well as in their first-degree relatives. RESULTS: The prevalence of CRC was similar between patients with confirmed serrated polyposis and multiple serrated polyps (odds ratio, 1.35; 95% confidence interval [CI], 0.64-2.82; P=.40). The SIR for CRC in patients with serrated polyposis (0.51; 95% CI, 0.01-2.82) did not differ significantly from the SIR for CRC in patients with multiple serrated polyps (0.74; 95% CI, 0.20-1.90; P=.70). The SIR for CRC also did not differ significantly between first-degree relatives of these groups (serrated polyposis: 3.28, 95% CI, 2.16-4.77; multiple serrated polyps: 2.79, 95% CI, 2.10-3.63; P =.50). Kaplan-Meier analysis showed no differences in the incidence of CRC between groups during the follow-up period (log-rank, 0.6). CONCLUSIONS: The risk of CRC in patients with multiple serrated polyps who do not meet the criteria for serrated polyposis, and in their first-degree relatives, is similar to that of patients diagnosed with serrated polyposis.

引用

页码：106 / +

页数：9

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