A dynamic look backward and forward

被引：28

作者：

Palmer, Arthur G., III ^{[1
]}

机构：

[1] Columbia Univ, Dept Biochem & Mol Biophys, 630 W 168th St, New York, NY 10032 USA

来源：

JOURNAL OF MAGNETIC RESONANCE | 2016年 / 266卷

基金：

美国国家卫生研究院;

关键词：

Chemical exchange; Conformational dynamics; Kinetics; Ligand binding; Molecular dynamics simulation; Nuclear magnetic resonance spectroscopy; Spin relaxation; NUCLEAR-MAGNETIC-RESONANCE; MODEL-FREE APPROACH; PANCREATIC TRYPSIN-INHIBITOR; SIDE-CHAIN DYNAMICS; CHEMICAL-EXCHANGE; TEMPERATURE-DEPENDENCE; BACKBONE DYNAMICS; NMR RELAXATION; ORDER PARAMETERS; R-1-RHO RELAXATION;

D O I：

10.1016/j.jmr.2016.01.018

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The 2015 Gunther Laukien Prize recognized solution NMR studies of protein dynamics and thermodynamics. This Perspective surveys aspects of the development and application of NMR spin relaxation for investigations of protein flexibility and function over multiple time scales in solution. Methods highlighted include analysis of overall rotational diffusion, theoretical descriptions of R-1 rho relaxation, and molecular dynamics simulations to interpret NMR spin relaxation. Applications are illustrated for the zinc-finger domain Xfin-31, the calcium-binding proteins calbindin D-9k and calmodulin, and the bZip transcription factor of GCN4. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：73 / 80

页数：8

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