Challenges and opportunities for large-scale electrophysiology with Neuropixels probes

被引：174
|
作者：
Steinmetz, Nicholas A. [1 ]
Koch, Christof [2 ]
Harris, Kenneth D. [1 ]
Carandini, Matteo [1 ]
机构：
[1] UCL, London, England
[2] Allen Inst Brain Sci, Seattle, WA USA
来源：
CURRENT OPINION IN NEUROBIOLOGY | 2018年 / 50卷
基金：
英国惠康基金;
关键词：
HIGH-DENSITY; MULTIELECTRODE ARRAY; NEURAL PROBE; RECORDINGS; HIPPOCAMPUS; MICROSTIMULATION; MICROELECTRODE; POLYTRODES; ELECTRODES; MULTISITE;
D O I：
10.1016/j.conb.2018.01.009
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Electrophysiological methods are the gold standard in neuroscience because they reveal the activity of individual neurons at high temporal resolution and in arbitrary brain locations. Microelectrode arrays based on complementary metal-oxide semiconductor (CMOS) technology, such as Neuropixels probes, look set to transform these methods. Neuropixels probes provide similar to 1000 recording sites on an extremely narrow shank, with on-board amplification, digitization, and multiplexing. They deliver low-noise recordings from hundreds of neurons, providing a step change in the type of data available to neuroscientists. Here we discuss the opportunities afforded by these probes for large-scale electrophysiology, the challenges associated with data processing and anatomical localization, and avenues for further improvements of the technology.
引用
收藏
页码：92 / 100
页数：9
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