Multi-layered functional membranes for periodontal regeneration: Preparation and characterization

被引：17
|
作者：
Gurbuz, Suhan [1 ]
Demirtas, T. Tolga [2 ]
Yuksel, Emre [3 ]
Karakecili, Ayse [3 ]
Dogan, Altan [1 ]
Gumusderelioglu, Menemse [4 ]
机构：
[1] Gazi Univ, Fac Dent, Dept Periodontol, TR-06510 Ankara, Turkey
[2] Hacettepe Univ, Dept Bioengn, TR-06800 Ankara, Turkey
[3] Ankara Univ, Fac Engn, Dept Chem Engn, TR-06100 Ankara, Turkey
[4] Hacettepe Univ, Dept Chem Engn, TR-06800 Ankara, Turkey
来源：
MATERIALS LETTERS | 2016年 / 178卷
关键词：
Multilayer structures; Biomaterials; Electrospinning; Solvent casting/particulate leaching; Poly(caprolactone);
D O I：
10.1016/j.matlet.2016.05.054
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Multi-layered biodegradable membranes (MLMs) were fabricated by combining electrospinning and solvent casting/particulate leaching methods. MLMs possess three layers of different functional properties; poly (caprolactone) (PCL)/nano-hydroxyapatite core layer and PCL/collagen, PCL/collagen-bone morphogenic protein 7 (BMP 7) outer layers on each side of the core layer. MC3T3-E1 cell culture tests showed that osteoblastic differentiation was enhanced on PCL/collagen BMP 7 layer. This facile method presents great potential for fabrication of multi-functional barrier membranes for periodontal regeneration as well as scaffolds possessing different properties to mimic complex extra cellular matrix structures with stable integrity. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：256 / 259
页数：4
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