Regulation of promoter activity through electrostatic interactions with RNA-polymerase

被引：0
|
作者：
Kamzolova, S. G. [1 ]
Osipov, A. A. [1 ]
Beskaravainyi, P. M. [1 ]
Dzhelyadin, T. R. [1 ]
Sorokin, A. A. [1 ]
机构：
[1] Russian Acad Sci, Inst Cell Biophys, Pushchino 142290, Moscow Region, Russia
来源：
BIOFIZIKA | 2007年 / 52卷 / 02期
关键词：
RNA-polymerase (E sigma(70)); promoter; electrostatic profile; RNA-polymerase-promoter recognition; regulation;
D O I：
暂无
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Electrostatic profiles for alpha(70)-specific promoters of T4 bacteriophage and four consensus-like synthetic promoters have been calculated. It was shown that the promoters can be classified according to the presence of some specific electrostatic elements located in the far upstream region of their DNAs. A correlation between the electrostatic elements specific for promoters and their functional behaviour was established. A general scheme of promotor activity regulation through electrostatic interactions between the upstream region of promoter DNA and the RNA-polymerase alpha-subunit was suggested.
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页码：228 / 236
页数：9
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