We address in this paper the autonomous derivation of re-use criteria, needed for channel assignment in channelized wireless voice and data communications systems, and of neighbor lists, needed for call-processing functions. We present an approach that relies on signal strength measurements collected by the system itself, during operation. This approach can be implemented with conventional equipment and functionality provided by the current air interface standards for circuit-based and packet-based access, employing either centralized or distributed control. No regularity requirements are imposed on the grid of cells or on the RF re-use pattern, and no knowledge is assumed of the base station locations. We describe the data collection mechanism and design the associated statistical hypothesis tests.