Learning-dependent neurogenesis in the olfactory bulb determines long-term olfactory memory

被引:119
|
作者
Sultan, S.
Mandairon, N.
Kermen, F.
Garcia, S.
Sacquet, J.
Didier, A. [1 ]
机构
[1] Univ Lyon 1, F-69007 Lyon, France
来源
FASEB JOURNAL | 2010年 / 24卷 / 07期
关键词
plasticity; associative learning; Zif268; D-CYCLOSERINE; ADULT NEUROGENESIS; ODOR RECOGNITION; MAMMALIAN BRAIN; GRANULE CELL; NEURONS; DISCRIMINATION; PLASTICITY; EXPERIENCE; INCREASES;
D O I
10.1096/fj.09-151456
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Inhibitory interneurons of the olfactory bulb are subjected to permanent adult neurogenesis. Their number is modulated by learning, suggesting that they could play a role in plastic changes of the bulbar network associated with olfactory memory. Adult male C57BL/6 mice were trained in an associative olfactory task, and we analyzed long-term retention of the task 5, 30, and 90 d post-training. In parallel, we assessed the fate of these newborn cells, mapped their distribution in the olfactory bulb and measured their functional implication using the immediate early gene Zif268. In a second set of experiments, we pharmacologically modulated glutamatergic transmission and using the same behavioral task assessed the consequences on memory retention and neurogenesis. Finally, by local infusion of an antimitotic drug, we selectively blocked neurogenesis during acquisition of the task and looked at the effects on memory retention. First we demonstrated that retrieval of an associative olfactory task recruits the newborn neurons in odor-specific areas of the olfactory bulb selected to survive during acquisition of the task and that it does this in a manner that depends on the strength of learning. We then demonstrated that acquisition is not dependent on neurogenesis if long-term retention of the task is abolished by blocking neurogenesis. Adult-born neurons are thus involved in changes in the neural representation of an odor; this underlies long-term olfactory memory as the strength of learning is linked to the duration of this memory. Neurogenesis thus plays a crucial role in long-term olfactory memory.-Sultan, S., Mandairon, N., Kermen, F., Garcia, S., Sacquet, J., Didier, A. Learning-dependent neurogenesis in the olfactory bulb determines long-term olfactory memory. FASEB J. 24, 2355-2363 (2010). www.fasebj.org
引用
收藏
页码:2355 / 2363
页数:9
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