NG-nitro-L-arginine methyl ester-induced potentiaton of the effect of aminophylline on rat diaphragm:: the role of extracellular calcium

被引：9
|
作者：
Stojanovic, R [1 ]
Todorovic, Z [1 ]
Nesic, Z [1 ]
Vuckovic, S [1 ]
Cerovac-Cosic, N [1 ]
Prostran, M [1 ]
机构：
[1] Univ Belgrade, Sch Med, Dept Clin Pharmacol Pharmacol & Toxicol, Belgrade, Serbia
来源：
JOURNAL OF PHARMACOLOGICAL SCIENCES | 2004年 / 96卷 / 04期
关键词：
aminophylline; calcium; N-G-nitro-L-arginine methyl ester;
D O I：
10.1254/jphs.SCE04001X
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The role of extracellular calcium in the interaction between intracellular cAMP and nitric oxide (NO)/cGMP on the contractility of rat diaphragm pretreated with cumulative concentrations of aminophylline (0.36 - 3.60 mM) was investigated. In a Ca2+-free medium, N-G-nitro-L-arginine methyl ester (L-NAME) (1 and 3 mM) depressed tension developed (Td) and also aminophylline-induced potentiation of Td in a concentration-dependent manner. Verapamil (2.5 muM) or nicardipine (20 muM) significantly antagonized the potentiating effect of L-NAME on Td in a calcium-containing medium. However, in the presence of verapamil or nicardipine, L-NAME still produced statistically significant potentiation of the cumulative concentrations of aminophylline (0.36 - 3.60 mM), given in the second series.
引用
收藏
页码：493 / 498
页数：6
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