Identifying the complex genetic architecture of growth and fatness traits in a Duroc pig population

被引：9
|
作者：
Zhang Zhe [1 ]
Chen Zi-tao [1 ]
Diao Shu-qi [1 ]
Ye Shao-pan [1 ]
Wang Jia-ying [1 ]
Gao Ning [1 ]
Yuan Xiao-long [1 ]
Chen Zan-mou [1 ]
Zhang Hao [1 ]
Li Jia-qi [1 ]
机构：
[1] South China Agr Univ, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Natl Engn Res Ctr Breeding Swine Ind, Coll Anim Sci, Guangzhou 510642, Peoples R China
来源：
JOURNAL OF INTEGRATIVE AGRICULTURE | 2021年 / 20卷 / 06期
基金：
中国国家自然科学基金;
关键词：
pig; GWAS; growth trait; fatness trait; candidate gene; GENOME-WIDE ASSOCIATION; BACKFAT THICKNESS; CANCER RISK; EXPRESSION;
D O I：
10.1016/S2095-3119(20)63264-6
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
In modern pig breeding programs, growth and fatness are vital economic traits that significantly influence porcine production. To identify underlying variants and candidate genes associated with growth and fatness traits, a total of 1 067 genotyped Duroc pigs with de-regressed estimated breeding values (DEBV) records were analyzed in a genome wide association study (GWAS) by using a single marker regression model. In total, 28 potential single nucleotide polymorphisms (SNPs) were associated with these traits of interest. Moreover, VPS4B, PHLPP1, and some other genes were highlighted as functionally plausible candidate genes that compose the underlying genetic architecture of porcine growth and fatness traits. Our findings contribute to a better understanding of the genetic architectures underlying swine growth and fatness traits that can be potentially used in pig breeding programs.
引用
收藏
页码：1607 / 1614
页数：8
相关论文
共 50 条
  • [1] Identifying the complex genetic architecture of growth and fatness traits in a Duroc pig population
    ZHANG Zhe
    CHEN Zi-tao
    DIAO Shu-qi
    YE Shao-pan
    WANG Jia-ying
    GAO Ning
    YUAN Xiao-long
    CHEN Zan-mou
    ZHANG Hao
    LI Jia-qi
    [J]. Journal of Integrative Agriculture, 2021, 20 (06) : 1607 - 1614
  • [2] Genetic Architecture of Feeding Behavior and Feed Efficiency in a Duroc Pig Population
    Ding, Rongrong
    Yang, Ming
    Wang, Xingwang
    Quan, Jianping
    Zhuang, Zhanwei
    Zhou, Shenping
    Li, Shaoyun
    Xu, Zheng
    Zheng, Enqin
    Cai, Gengyuan
    Liu, Dewu
    Huang, Wen
    Yang, Jie
    Wu, Zhenfang
    [J]. FRONTIERS IN GENETICS, 2018, 9
  • [3] Identifying Genetic Architecture of Carcass and Meat Quality Traits in a Ningxiang Indigenous Pig Population
    Yin, Shishu
    Song, Gang
    Gao, Ning
    Gao, Hu
    Zeng, Qinghua
    Lu, Peng
    Zhang, Qin
    Xu, Kang
    He, Jun
    [J]. GENES, 2023, 14 (07)
  • [4] Detection of quantitative trait loci for growth- and fatness-related traits in a large-scale White Duroc x Erhualian intercross pig population
    Ai, H.
    Ren, J.
    Zhang, Z.
    Ma, J.
    Guo, Y.
    Yang, B.
    Huang, L.
    [J]. ANIMAL GENETICS, 2012, 43 (04) : 383 - 391
  • [5] The Genetic Architecture of Meat Quality Traits in a Crossbred Commercial Pig Population
    Zhuang, Zhanwei
    Wu, Jie
    Xu, Cineng
    Ruan, Donglin
    Qiu, Yibin
    Zhou, Shenping
    Ding, Rongrong
    Quan, Jianping
    Yang, Ming
    Zheng, Enqin
    Wu, Zhenfang
    Yang, Jie
    [J]. FOODS, 2022, 11 (19)
  • [6] The Impact of Population Demography and Selection on the Genetic Architecture of Complex Traits
    Lohmueller, Kirk E.
    [J]. PLOS GENETICS, 2014, 10 (05):
  • [7] Identification of genetic markers associated with fatness and leg weakness traits in the pig
    Fan, B.
    Onteru, S. K.
    Nikkilae, M. T.
    Stalder, K. J.
    Rothschild, M. F.
    [J]. ANIMAL GENETICS, 2009, 40 (06) : 967 - 970
  • [8] Genome-Wide Association Study for Reproductive Traits in a Duroc Pig Population
    Zhang, Zhe
    Chen, Zitao
    Ye, Shaopan
    He, Yingting
    Huang, Shuwen
    Yuan, Xiaolong
    Chen, Zanmou
    Zhang, Hao
    Li, Jiaqi
    [J]. ANIMALS, 2019, 9 (10):
  • [9] A further look at quantitative trait loci for growth and fatness traits in a White Duroc x Erhualian F3 intercross population
    Deng, Zheng
    Huang, Tao
    Yan, Guorong
    Yang, Bin
    Zhang, Zhiyan
    Xiao, Shijun
    Ai, Huashui
    Huang, Lusheng
    [J]. ANIMAL BIOTECHNOLOGY, 2022, 33 (06) : 1205 - 1216
  • [10] Weighted Single-Step GWAS Identified Candidate Genes Associated with Growth Traits in a Duroc Pig Population
    Ruan, Donglin
    Zhuang, Zhanwei
    Ding, Rongrong
    Qiu, Yibin
    Zhou, Shenping
    Wu, Jie
    Xu, Cineng
    Hong, Linjun
    Huang, Sixiu
    Zheng, Enqin
    Cai, Gengyuan
    Wu, Zhenfang
    Yang, Jie
    [J]. GENES, 2021, 12 (01) : 1 - 15
12345