共 1 条
Transition dynamics of generalized multiple epileptic seizures associated with thalamic reticular nucleus excitability: A computational study
被引:16
|作者:
Liu, Suyu
[1
]
Wang, Qingyun
[1
]
机构:
[1] Beihang Univ, Dept Dynam & Control, Beijing 100191, Peoples R China
来源:
基金:
中国国家自然科学基金;
关键词:
Transition dynamics;
Bifurcation;
GABA(A) receptor;
AMPA receptor;
Epileptic seizures;
ABSENCE SEIZURES;
AMPA RECEPTORS;
ANIMAL-MODELS;
NEURONS;
MODULATION;
MECHANISMS;
BRAIN;
SPIKE;
D O I:
10.1016/j.cnsns.2017.04.035
中图分类号:
O29 [应用数学];
学科分类号:
070104 ;
摘要:
Presently, we improve a computational framework of thalamocortical circuits related to the Taylor's model to investigate the relationship between thalamic reticular nucleus (RE) excitability and epilepsy. By using bifurcation analysis, we explore the RE's excitability dynamics mechanism in the processes of seizure generation, development and transition. Results show that the seizure-free state, absence seizures, clonic seizures and tonic seizures can be formed as the RE excitability is changed in this established model. Importantly, it is verified that physiological changing GABA(A) inhibition in RE can elicit absence seizures and clonic seizures and the pathological transitions between these two seizures. Furthermore, when the level of AMPA connection is decreased or increased, this proposed model embraces absence seizures and clonic seizures, and tonic seizures, respectively. Except that, bifurcation mechanisms of dynamical transition of different seizures are analyzed in detail. In addition, hybrid regulations of the reticular nucleus excitability for epileptic seizures are proven to be valid within the suitable levels of AMPA and GABAA connection. Hopefully, the obtained results could be helpful for effective control of epileptic activities with additional pharmacological interference. (C) 2017 Elsevier B.V. All rights reserved.
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页码:203 / 213
页数:11
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