Design, synthesis and molecular docking studies of novel triazole antifungal compounds

被引：9
|
作者：
He, Qiu Qin [1 ]
Li, Ke [1 ]
Cao, Yong Bing [1 ]
Dong, Huan Wen [1 ]
Zhao, Li Hua [1 ]
Liu, Chao Mei [1 ]
Sheng, Chun Quan [1 ]
机构：
[1] Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2007年 / 18卷 / 06期
基金：
中国国家自然科学基金;
关键词：
lanosterol; 14; alpha-demethylase; triazole; tert-butyl; antifungal activity; fluconazole-resistant;
D O I：
10.1016/j.cclet.2007.04.025
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Based on the active site of Candida albicans lanosterol 14 alpha-demethylase (CACYP51), novel triazole compounds structurally different from the current triazole drugs were designed and synthesized. In vitro antifungal activities showed that compounds 10, 11, 16 and 20 exhibited strong activities. In addition, compounds 10, 11 and 16 also displayed certain activities against fluconazole-resistant fungi. (C) 2007 Chao Mei Liu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
引用
收藏
页码：663 / 666
页数：4
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