Oral tolerance: Immune mechanisms and treatment of autoimmune diseases

被引：609
|
作者：
Weiner, HL [1 ]
机构：
[1] HARVARD UNIV, SCH MED, BOSTON, MA 02115 USA
来源：
IMMUNOLOGY TODAY | 1997年 / 18卷 / 07期
关键词：
D O I：
10.1016/S0167-5699(97)01053-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Orally administered proteins induce systemic hyporesponsiveness to the fed protein. The mechanism underlying such 'oral tolerance' depends on the amount of antigen fed, with higher doses inducing deletion and anergy, and lower doses inducing regulatory cells. Orally administered autoantigens suppress many experimental autoimmune diseases, as discussed here by Howard Weiner.
引用
收藏
页码：335 / 343
页数：9
相关论文
共 50 条
  • [1] Mechanisms of oral tolerance and treatment of autoimmune diseases
    Weiner, HL
    [J]. HLA AND DISEASE - THE MOLECULAR BASIS, 1997, 40 : 423 - 440
  • [2] Oral tolerance: Immunologic mechanisms and treatment of autoimmune diseases
    Weiner, HL
    [J]. ESSENTIALS OF MUCOSAL IMMUNOLOGY, 1996, : 555 - 561
  • [3] Oral tolerance: Elucidation of mechanisms and application to treatment of autoimmune diseases
    Fowler, E
    Weiner, HL
    [J]. BIOPOLYMERS, 1997, 43 (04) : 323 - 335
  • [4] Oral tolerance for the treatment of autoimmune diseases
    Weiner, HL
    [J]. ANNUAL REVIEW OF MEDICINE, 1997, 48 : 341 - 351
  • [5] Oral tolerance in the treatment of inflammatory autoimmune diseases
    Wardrop III R.M.
    Whitacre C.C.
    [J]. Inflammation Research, 1999, 48 (3) : 106 - 119
  • [6] Oral tolerance in the treatment of inflammatory autoimmune diseases
    Wardrop, RM
    Whitacre, CC
    [J]. INFLAMMATION RESEARCH, 1999, 48 (03) : 106 - 119
  • [7] ORAL TOLERANCE: A WAY TO REDIRECT THE IMMUNE SYSTEM IN AUTOIMMUNE DISEASES 8
    P G Vlachoyiannopoulos
    [J]. Pediatric Research, 1997, 41 (5) : 731 - 731
  • [8] Nanoparticle-based approaches to immune tolerance for the treatment of autoimmune diseases
    Serra, Pau
    Santamaria, Pere
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2018, 48 (05) : 751 - 756
  • [9] Oral tolerance: Therapeutic implications for autoimmune diseases
    Faria, Ana M. C.
    Weiner, Howard L.
    [J]. CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2006, 13 (2-4): : 143 - 157
  • [10] ORAL TOLERANCE - IMMUNOLOGICAL MECHANISMS AND TREATMENT OF ANIMAL AND HUMAN ORGAN-SPECIFIC AUTOIMMUNE-DISEASES BY ORAL-ADMINISTRATION OF AUTOANTIGENS
    WEINER, HL
    FRIEDMAN, A
    MILLER, A
    KHOURY, SJ
    ALSABBAGH, A
    SANTOS, L
    SAYEGH, M
    NUSSENBLATT, RB
    TRENTHAM, DE
    HAFLER, DA
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 1994, 12 : 809 - 837
12345