A Method for Improving the Efficiency of Therapy for Melanoma

被引：2
|
作者：
Nikitina, R. G. [1 ]
Mardynskaja, V. P. [1 ]
Morozova, T. G. [1 ]
Drozhzhina, V. V. [1 ]
机构：
[1] Russian Acad Med Sci, Med Radiol Ctr, Obninsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2009年 / 148卷 / 02期
关键词：
melanoma; photodynamic therapy; laser;
D O I：
10.1007/s10517-009-0658-0
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
A method for photodynamic therapy was developed in experiments on the model of melanoma B16. The photosensitizer is injected by two doses, while laser exposure is carried out during coincidence of its maximum accumulation phases in tumor vessels and cells. This method increased the percentage of animals with complete regression of the tumor, decreased the coefficient of absolute tumor increase in animals with progressive tumor growth, increased survival of mice, and significantly decreased melanoma metastasizing to the lungs in comparison with untreated animals and even with the standard photodynamic therapy.
引用
收藏
页码：238 / 240
页数：3
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