Single-Nucleus Transcriptomic Analysis Reveals Important Cell Cross-Talk in Diabetic Kidney Disease

被引：12

作者：

Wei, Yi ^{[1
]}

Gao, Xiang ^{[2
]}

Li, Aihua ^{[1
]}

Liang, Mengjun ^{[1
]}

Jiang, Zongpei ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Nephrol, Guangzhou, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Gastroenterol, Guangzhou, Peoples R China

来源：

FRONTIERS IN MEDICINE | 2021年 / 8卷

关键词：

single-cell sequencing; cell cross-talk; diabetic kidney disease; CellPhoneDB; glomerulotubular communication; GROWTH-FACTOR; CANAGLIFLOZIN;

D O I：

10.3389/fmed.2021.657956

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetic kidney disease (DKD) leads to the loss of renal function and cell cross-talk is one of the crucial mechanisms participating in the pathogenesis of DKD. However, the mechanisms of cell communication were not fully elucidated in previous studies. In this study, we performed cell cross-talk analysis using CellPhoneDB based on a single-nucleus transcriptomic dataset (GSE131882) and revealed the associations between cell communication-related genes and renal function, providing overall insight into cell communication in DKD. In addition, this study may facilitate the discovery of novel mechanisms, promising biomarkers, and therapeutic targets that are clinically beneficial to patients.

引用

页数：11

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