In Vitro and In Vivo Antifungal Activity of AmBisome Compared to Conventional Amphotericin B and Fluconazole against Candida auris

被引：9
|
作者：
Herrada, Janet [1 ,2 ]
Gamal, Ahmed [1 ,2 ]
Long, Lisa [1 ,2 ]
Sanchez, Sonia P. [3 ]
McCormick, Thomas S. [1 ,2 ]
Ghannoum, Mahmoud A. [1 ,2 ]
机构：
[1] Univ Hosp Cleveland, Med Ctr, Ctr Med Mycol, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Cleveland, OH 44106 USA
[3] Gilead Sci Europe Ltd, Uxbridge, Middx, England
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2021年 / 65卷 / 06期
基金：
美国国家卫生研究院;
关键词：
Candida auris; multidrug resistant; AmBisome; conventional amphotericin B; fluconazole; susceptibility testing; mouse models; CLONAL STRAIN; NEW-YORK; SUSCEPTIBILITY; FORMULATIONS; RESISTANT; EFFICACY;
D O I：
10.1128/AAC.00306-21
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Antifungal activity of AmBisome against Candida auris was determined in vitro and in vivo. AmBisome showed MIC50 and MIC90 values of 1 and 2 mu g/ml, respectively. Unlike conventional amphotericin B, significant in vivo efficacy was observed in the AmBisome 7.5mg/kg treatment group in survival and reduction of kidney tissue fungal burden compared to the untreated group. Our data show that AmBisome has significant antifungal activity against C. auris infection in vitro and in vivo.
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页数：4
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