Japonicones E-L, Dimeric Sesquiterpene Lactones from Inula japonica Thunb.

被引：56

作者：

Qin, Jiang Jiang ^{[1
]}

Jin, Hui Zi ^{[1
]}

Zhu, Jia Xian ^{[1
]}

Fu, Jian Jun ^{[1
]}

Hu, Xiao Jia ^{[1
]}

Liu, Xiao Hua ^{[2
]}

Zhu, Yan ^{[1
]}

Yan, Shi Kai ^{[1
]}

Zhang, Wei Dong ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

[2] Second Mil Med Univ, Dept Phytochem, Shanghai, Peoples R China

来源：

PLANTA MEDICA | 2010年 / 76卷 / 03期

基金：

中国博士后科学基金;

关键词：

japonicones E-L; sesquiterpene dimmer; Inula japonica Thunb; Asteraceae; NO production; CONSTITUENTS; BRITANNICA;

D O I：

10.1055/s-0029-1186065

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Eight new dimeric sesquiterpene lactones (japonicones E-L, 1-8), including a novel sesquiterpene dimer bearing a rare hydroperoxide group (japonicone E, 1), were isolated from the aerial part of Inula japonica Thunb. Their structures were determined mainly by the use of 1D and 2D NMR spectroscopic techniques including HSQC, H-1-H-1 COSY, HMBC, and NOESY. All the isolates were tested for inhibitory effects against LPS-induced NO production in RAW264.7 macrophages. Among the compounds tested, japonicone F (2) showed the strongest activity with the IC50 value of 4.1 mu g/mL.

引用

页码：278 / 283

页数：6

共 50 条

[1] Japonicones Q-T, four new dimeric sesquiterpene lactones from Inula japonica Thunb.
Zhu, Jia Xian
Qin, Jiang Jiang
Jin, Hui Zi
Zhang, Wei Dong
FITOTERAPIA, 2013, 84 : 40 - 46
[2] Japonicones A-D, bioactive dimeric sesquiterpenes from Inula japonica Thunb.
Qin, Jiang Jiang
Jin, Hui Zi
Fu, Jian Jun
Hu, Xiao Jia
Wang, Yan
Yan, Shi Kai
Zhang, Wei Dong
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (03) : 710 - 713
[3] Japonicones A-D, bioactive dimeric sesquiterpenes from Inula japonica Thunb. (vol 19, pg 710, 2009)
Qin, Jiang Jiang
Jin, Hui Zi
Fu, Jian Jun
Hu, Xiao Jia
Wang, Yan
Yan, Shi Kai
Zhang, Wei Dong
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (18) : 5584 - 5584
[4] SESQUITERPENE LACTONES FROM INULA-JAPONICA
EVSTRATOVA, RI
SHEICHENKO, VI
RYBALKO, KS
KHIMIYA PRIRODNYKH SOEDINENII, 1974, (06): : 730 - 733
[5] Antitumour Activities of Sesquiterpene Lactones from Inula helenium and Inula japonica
Li, Yong
Ni, Zhi-Yu
Zhu, Meng-Chu
Dong, Mei
Wang, Si-Ming
Shi, Qing-Wen
Zhang, Man-Li
Wang, Yu-Fang
Huo, Chang-hong
Kiyota, Hiromasa
Cong, Bin
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, 2012, 67 (7-8): : 375 - 380
[6] Identification and structural characterization of dimeric sesquiterpene lactones in Inula japonica Thunb. by high-performance liquid chromatography/electrospray ionization with multi-stage mass spectrometry
Ye, Ji
Qin, Jiang-Jiang
Su, Juan
Lin, Shan
Huang, Ying
Jin, Hui-Zi
Zhang, Wei-Dong
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2013, 27 (19) : 2159 - 2169
[7] Dimeric Sesquiterpene Lactones from Inula falconeri with significant cytotoxicity
Cheng, Xiang-Rong
Zhang, Wei-Dong
Le, Guo-Wei
FASEB JOURNAL, 2016, 30
[8] Sesquiterpene Monomers and Dimers From the Flower of Inula japonica Thunb. With Selective Antiproliferation Against Breast Cancer Cells
Chen, Hong-Yu
Guo, Lu
Luo, Di
Lou, Si-Qing
Liang, Dong-E.
Xu, Xin-Ya
Xi, Zhi-Fang
Zhan, Zha-Jun
Ma, Lie-Feng
CHEMISTRY & BIODIVERSITY, 2025,
[9] Targeted isolation of dimeric sesquiterpene lactones and sesquiterpene derivatives from the roots of Inula helenium
Han, Jae Sang
Kim, Jun Gu
Cho, Yong Beom
An, Beom Kyun
Lee, Dongho
Lee, Mi Kyeong
Hwang, Bang Yeon
PHYTOCHEMISTRY, 2025, 229
[10] Sesquiterpene lactones from Inula montana L.
González-Romero, MA
Villaescusa-Castillo, L
Díaz-Lanza, AM
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, 2000, 55 (9-10): : 697 - 700

← 1 2 3 4 5 →