Mesenchymal Stem Cell Therapy in Ischemic Stroke: A Meta-analysis of Preclinical Studies

被引：41

作者：

Sarmah, Deepaneeta ^{[1
]}

Agrawal, Vishal ^{[2
]}

Rane, Pallavi ^{[1
]}

Bhute, Shashikala ^{[1
]}

Watanabe, Mitsuyoshi ^{[3
]}

Kalia, Kiran ^{[1
]}

Ghosh, Zhumur ^{[4
]}

Dave, Kunjan R. ^{[3
]}

Yavagal, Dileep R. ^{[3
]}

Bhattacharya, Pallab ^{[1
,5
]}

机构：

[1] NIPER, Dept Pharmacol & Toxicol, Gandhinagar, Gujarat, India

[2] NIPER, Dept Med Devices, Gandhinagar, Gujarat, India

[3] Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA

[4] Bose Inst, Dept Bioinformat, Kolkata, India

[5] Harvard Med Sch, Boston Childrens Hosp, Boston, MA 02115 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2018年 / 103卷 / 06期

关键词：

ENDOTHELIAL GROWTH-FACTOR; MARROW MONONUCLEAR-CELLS; STROMAL CELLS; CEREBRAL-ISCHEMIA; INTRAARTERIAL DELIVERY; PROGENITOR CELLS; BRAIN-INJURY; TRANSPLANTATION; RECOVERY; RATS;

D O I：

10.1002/cpt.927

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Numerous preclinical studies have been carried out using mesenchymal stem cells (MSCs) therapy for ischemic stroke. The purpose of the present meta-analysis is to review the quality of preclinical studies. In all, 4,361 articles were identified, out of which 64 studies were included (excluding in vitro studies). The results were obtained across species, route, and time of administration, immunogenicity, and doses. The median quality score 4.90/10, confidence interval 95%, and large effect size were observed, which strongly supports the translation potential of MSC therapy for ischemic stroke.

引用

页码：990 / 998

页数：9

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