Metalation of t-butyl sulfoxides, sulfones and sulfonamides of pyridazine and pyrazine. Metalation of diazines. XX

被引：19

作者：

Turck, A ^{[1
]}

Ple, N ^{[1
]}

Pollet, P ^{[1
]}

Queguiner, G ^{[1
]}

机构：

[1] INSA, IRCOF, Lab Chim Organ Fine & Heterocycl, UPRESA 6014, F-76131 Mt St Aignan, France

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1998年 / 35卷 / 02期

关键词：

D O I：

10.1002/jhet.5570350228

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the pyridazine series, the use of tert-butylsulfinyl and tert-butylsulfonyl as ortho directing groups for metalation has been tested. Various functionalized products were obtained in good yields. In the case of 3-tert-butylsulfinyl-6-methoxypyridazine the metalation was regioselective in ortho to the sulfinyl group. The metalation of 2-tert-butylsulfinyl and 2-tert-butylsulfonylpyrazine gave low to moderate yields. Synthesis of diazinesulfonamides were improved and the metalation of N-tert-butylsulfonamidopyrazine was achieved.

引用

页码：429 / 436

页数：8