Morphine-Induced Dendritic Spine Remodeling in Rat Nucleus Accumbens Is Corticosterone Dependent

被引:9
|
作者
Geoffroy, Helene [1 ,2 ,3 ]
Canestrelli, Corinne [1 ,2 ,3 ]
Marie, Nicolas [1 ,2 ,3 ]
Noble, Florence [1 ,2 ,3 ]
机构
[1] CNRS, Paris, France
[2] INSERM, Paris, France
[3] Univ Paris 05, Paris, France
来源
关键词
morphine; nucleus accumbens shell; nucleus accumbens core; dendritic spines; adrenalectomy; INDUCED MORPHOLOGICAL-CHANGES; PHYSICAL-DEPENDENCE; GENE-EXPRESSION; WITHDRAWAL; PLASTICITY; STRESS;
D O I
10.1093/ijnp/pyz014
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Chronic morphine treatments produce important morphological changes in multiple brain areas including the nucleus accumbens. Methods: In this study, we have investigated the effect of chronic morphine treatment at a relatively low dose on the morphology of medium spiny neurons in the core and shell of the nucleus accumbens in rats 1 day after the last injection of a chronic morphine treatment (5 mg/kg once per day for 14 days). Medium spiny neurons were labeled with 1,1' dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate crystal and analyzed by confocal laser-scanning microscope. Results: Our results show an increase of thin spines and a decrease of stubby spines specifically in the shell of morphine-treated rats compared with control. Since morphine-treated rats also presented an elevation of corticosterone level in plasma, we explored whether spine alterations induced by morphine treatment in the nucleus accumbens could be affected by the depletion of the hormone. Thus, bilaterally adrenalectomized rats were treated with morphine in the same conditions. No more alteration in stubby spines in the shell was detected in morphine-treated rats with a depletion of corticosterone, while a significant increase was observed in mushroom spines in the shell and stubby spines in the core. Regarding the thin spines, the increase observed with morphine compared with saline was lower in adrenalectomized rats than in nonadrenalectomized animals. Conclusion: These results indicate that dendritic spine remodeling in nucleus accumbens following chronic morphine treatment at relatively low doses is dependent on corticosterone levels.
引用
收藏
页码:394 / 401
页数:8
相关论文
共 50 条
  • [1] Ghrelin and endocannabinoids participation in morphine-induced effects in the rat nucleus accumbens
    Sustkova-Fiserova, Magdalena
    Jerabek, Pavel
    Havlickova, Tereza
    Syslova, Kamila
    Kacer, Petr
    [J]. PSYCHOPHARMACOLOGY, 2016, 233 (03) : 469 - 484
  • [2] Ghrelin and endocannabinoids participation in morphine-induced effects in the rat nucleus accumbens
    Magdalena Sustkova-Fiserova
    Pavel Jerabek
    Tereza Havlickova
    Kamila Syslova
    Petr Kacer
    [J]. Psychopharmacology, 2016, 233 : 469 - 484
  • [3] Nitric oxide mediation of morphine-induced place preference in the nucleus accumbens of rat
    Gholami, A
    Haeri-Rohani, A
    Sahraie, H
    Zarrindast, MR
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2002, 449 (03) : 269 - 277
  • [4] Cocaine- and Morphine-Induced Synaptic Plasticity in the Nucleus Accumbens
    Alcantara, Adriana A.
    Lim, Helen Y.
    Floyd, Christopher E.
    Garces, Juanita
    Mendenhall, John M.
    Lyons, Chelsea L.
    Berlanga, Monica L.
    [J]. SYNAPSE, 2011, 65 (04) : 309 - 320
  • [5] GABAA receptors in VTA mediate the morphine-induced release of ascorbic acid in rat nucleus accumbens
    Sun, Ji-Ye
    Yang, Jing-Yu
    Wang, Fang
    Hou, Yue
    Dong, Ying-Xu
    Wu, Chun-Fu
    [J]. BRAIN RESEARCH, 2011, 1368 : 52 - 58
  • [6] Prefrontal cortex serotonin, stress, and morphine-induced nucleus accumbens dopamine
    Bland, ST
    Schmid, MJ
    Watkins, LR
    Maier, SF
    [J]. NEUROREPORT, 2004, 15 (17) : 2637 - 2641
  • [7] Gabapentin Completely Attenuated the Acute Morphine-Induced c-Fos Expression in the Rat Nucleus Accumbens
    Jamil Ahsan Kazi
    Mohamed Ibrahim Abu-Hassan
    [J]. Journal of Molecular Neuroscience, 2011, 45 : 101 - 109
  • [8] Baclofen antagonizes nicotine-, cocaine-, and morphine-induced dopamine release in the nucleus accumbens of rat
    Fadda, P
    Scherma, M
    Fresu, A
    Collu, M
    Fratta, W
    [J]. SYNAPSE, 2003, 50 (01) : 1 - 6
  • [9] Gabapentin Completely Attenuated the Acute Morphine-Induced c-Fos Expression in the Rat Nucleus Accumbens
    Kazi, Jamil Ahsan
    Abu-Hassan, Mohamed Ibrahim
    [J]. JOURNAL OF MOLECULAR NEUROSCIENCE, 2011, 45 (02) : 101 - 109
  • [10] Repeated administration of dopaminergic agents in the nucleus accumbens and morphine-induced place preference
    Zarrindast, MR
    Azami, BN
    Rostami, P
    Rezayof, A
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2006, 169 (02) : 248 - 255