Two new cytotoxic cycloartane triterpenoids from Aphanamixis polystachya (Wall.) R. N. Parker

被引：8

作者：

Wang, Yi-ting ^{[1
,2
]}

Fan, Shi-rui ^{[1
,2
]}

Cai, Jie-yun ^{[1
,3
]}

Guo, Jing-jing ^{[1
]}

Zhang, Xin-fang ^{[1
,2
]}

Yang, Bi-juan ^{[1
]}

Hao, Xiao-jiang ^{[1
]}

Chen, Duo-zhi ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China

[2] Yunnan Univ, Dept Chem Sci & Engn, Kunming, Yunnan, Peoples R China

[3] Yunnan Tobacco Qual Supervis & Test Stn, Kunming, Yunnan, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2022年 / 36卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Cytotoxic; cycloartane triterpenoid; Aphanamixis polystachya; LEAVES;

D O I：

10.1080/14786419.2021.1906242

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Two new cycloartane triterpenoids, (24 R)-cycloartane-3 beta,24,25,30-tetrol (1) and (24 R)-24,25,30-trihydroxy-9,19-cycloartane-3-one (2), along with three known compounds (3-5) were isolated from leaves and twigs of Aphanamixis polystachya. The new compounds were elucidated based on comprehensive spectroscopic analysis, including 1 D, 2 D NMR and HREIMS. The in vitro cytotoxic activities evaluation of five human cancer cell lines revealed that compound 1 exhibited cytotoxic activity on all of tested human cancer cell lines, while compound 2 only had specific activity on SMMC-7721 cell line.

引用

页码：2473 / 2478

页数：6

共 19 条

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BANGLADESH JOURNAL OF BOTANY, 2017, 46 (04): : 1381 - 1387
[2] Aphapolins A and B: Two Nemoralisin Diterpenoids Isolated from Aphanamixis polystachya (Wall.) R. Parker
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Wu, Xiao-Zhen
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Li, Ya
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EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2017, 2017 (30) : 4429 - 4433
[3] Two novel nornemoralisin-type diterpenoids from Aphanamixis polystachya (Wall.) R. Parker
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Fang, Fu-Hu
Huang, Wen-Jun
Shi, Ying-Ying
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FITOTERAPIA, 2020, 140
[4] Evaluation of Aphanamixis polystachya (Wall.) R. Parker as a potential source of biodiesel
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Channarayappa
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JOURNAL OF BIOCHEMICAL TECHNOLOGY, 2012, 3 (05) : S128 - S133
[5] Potential SARS-CoV-2 M pro steroid inhibitors from Aphanamixis polystachya (Wall.) R. N. Parker
Ren, Juan
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FITOTERAPIA, 2024, 177
[6] Antimicrobial activity of oil and crude alkaloids from seeds of Aphanamixis polystachya (Wall.) R.N.!Parker
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[7] Two new triterpenoids from the fruits of Aphanamixis polystachya
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JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2022, 24 (08) : 738 - 745
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TETRAHEDRON LETTERS, 1967, (16) : 1471 - +
[9] A comprehensive apoptotic assessment of niloticin in cervical cancer cells: a tirucallane-type triterpenoid from Aphanamixis polystachya (Wall.) Parker
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RSC MEDICINAL CHEMISTRY, 2024, 15 (10): : 3444 - 3459
[10] Two New Tirucallane-Type Triterpenoids from the Stem Barks of Aphanamixis grandifolia and Their Cytotoxic Activities
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CHINESE JOURNAL OF CHEMISTRY, 2012, 30 (06) : 1356 - 1360

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