Prediction of octanol-water partition coefficients (log P) of drugs by micellar liquid chromatography simulating biomembrane

Brij35 micellar liquid chromatography (MLC) was presented for prediction of the octanol-water partition coefficient (log P) of drugs by comparing the retention factors of drugs in different surfactants with log P in literature. The results showed that the retention factors of drugs in Brij35 MLC were related with log P of drugs in literature. The effect of Brij35 concentration on the retention of drugs was studied and the relationship was established between the retention factors of drugs in surfactant of different concentration and log P. This method is simple, rapid and can provide valuable reference information for hydrophobicity of drugs.