KDM5A demethylase: Erasing histone modifications to promote repair of DNA breaks

被引：8
|
作者：
Price, Brendan D. [1 ]
机构：
[1] Harvard Med Sch, Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02115 USA
来源：
JOURNAL OF CELL BIOLOGY | 2017年 / 216卷 / 07期
基金：
美国国家卫生研究院;
关键词：
DOUBLE-STRAND BREAKS; HOMOLOGOUS RECOMBINATION; CHROMATIN; ZMYND8; DAMAGE;
D O I：
10.1083/jcb.201705005
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Repairing DNA breaks within the complexity of the cell chromatin is challenging. In this issue, Gong et al. (2017. J. Cell Biol. https ://doi.org/10.1083/jcb.201611135) identify the histone demethylase KDM5A as a critical editor of the cells' "histone code" that is required to recruit DNA repair complexes to DNA breaks.
引用
收藏
页码：1871 / 1873
页数：3
相关论文
共 50 条
  • [1] Histone demethylase KDM5A regulates the ZMYND8-NuRD chromatin remodeler to promote DNA repair
    Gong, Fade
    Clouaire, Thomas
    Aguirrebengoa, Marion
    Legube, Gaelle
    Miller, Kyle M.
    [J]. JOURNAL OF CELL BIOLOGY, 2017, 216 (07): : 1959 - 1974
  • [2] Allosteric control of histone demethylase KDM5A
    Longbotham, James
    Chio, Cynthia
    Kelly, Mark
    Fujimori, Danica
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 253
  • [3] The Roles of the Histone Demethylase KDM5A in Breast Cancer and Senescence
    McCabe, Thomas J.
    Lang, Sabine
    Aoshima, Keisuke
    Wu, Lizhen
    Cao, Jian
    Yan, Qin
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2022, 192 (09): : S2 - S2
  • [4] Histone demethylase KDM5A promotes tumorigenesis of osteosarcoma tumor
    Daohu Peng
    Birong Lin
    Mingzhong Xie
    Ping Zhang
    QingXi Guo
    Qian Li
    Qinwen Gu
    Sijin Yang
    Li Sen
    [J]. Cell Death Discovery, 7
  • [5] Histone demethylase KDM5A promotes tumorigenesis of osteosarcoma tumor
    Peng, Daohu
    Lin, Birong
    Xie, Mingzhong
    Zhang, Ping
    Guo, QingXi
    Li, Qian
    Gu, Qinwen
    Yang, Sijin
    Sen, Li
    [J]. CELL DEATH DISCOVERY, 2021, 7 (01)
  • [6] The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma
    Banelli, Barbara
    Carra, Elisa
    Barbieri, Federica
    Wuerth, Roberto
    Parodi, Federica
    Pattarozzi, Alessandra
    Carosio, Roberta
    Forlani, Alessandra
    Allemanni, Giorgio
    Marubbi, Daniela
    Florio, Tullio
    Daga, Antonio
    Romani, Massimo
    [J]. CELL CYCLE, 2015, 14 (21) : 3418 - 3429
  • [7] Role of Oxygen Sensing Histone Demethylase KDM5A in Wound Healing
    Jackson, Jasmine R.
    Takahashi, Kentaro
    Liu, Jinghua
    Akasaka, Yoshikiyo
    Urao, Norifumi
    [J]. WOUND REPAIR AND REGENERATION, 2023, 31 (02) : 266 - 266
  • [8] Extended Recognition of the Histone H3 Tail by Histone Demethylase KDM5A
    Petronikolou, Nektaria
    Longbotham, James E.
    Fujimori, Danica Galonic
    [J]. BIOCHEMISTRY, 2020, 59 (05) : 647 - 651
  • [9] Drawing a line between histone demethylase KDM5A and KDM5B: their roles in development and tumorigenesis
    Jung Yoo
    Go Woon Kim
    Yu Hyun Jeon
    Ji Yoon Kim
    Sang Wu Lee
    So Hee Kwon
    [J]. Experimental & Molecular Medicine, 2022, 54 : 2107 - 2117
  • [10] Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds
    Horton, John R.
    Liu, Xu
    Gale, Molly
    Wu, Lizhen
    Shanks, John R.
    Zhang, Xing
    Webber, Philip J.
    Bell, Joshua S. K.
    Kales, Stephen C.
    Mott, Bryan T.
    Rai, Ganesha
    Jansen, Daniel J.
    Henderson, Mark J.
    Urban, Daniel J.
    Hall, Matthew D.
    Simeonov, Anton
    Maloney, David J.
    Johns, Margaret A.
    Fu, Haian
    Jadhav, Ajit
    Vertino, Paula M.
    Yan, Qin
    Cheng, Xiaodong
    [J]. CELL CHEMICAL BIOLOGY, 2016, 23 (07): : 769 - 781
12345