Comorbidity with ADHD decreases response to pharmacotherapy in children and adolescents with acute mania:: Evidence from a metaanalysis

被引:29
|
作者
Consoli, Angele
Bouzamondo, Anissa
Guile, Jean-Marc
Lechat, Philippe
Cohen, David
机构
[1] Univ Paris 06, Serv Psychiat Enfant & Adolescent, Dept Child & Adolescent Psychiat, Grp Hosp Pitie Salpetriere,AP HP, F-75641 Paris 13, France
[2] CNRS, FRE 2987, Paris, France
[3] Univ Paris 06, Dept Pharmacol, AP HP, Hop La Pitie Salpetriere, F-75641 Paris 13, France
[4] Univ Montreal, Dept Psychiat, Montreal, PQ H3C 3J7, Canada
关键词
bipolar disorder; attention-deficit hyperactivity disorder; child; adolescent; acute treatment; metaanalysis;
D O I
10.1177/070674370705200507
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: To assess whether comorbid attention-deficit hyperactivity disorder (ADHD) influences response to treatment in young patients with acute mania. Methods: We conducted a metaanalysis of 5 open trials of 100, 35, 41, 60, and 37 children and adolescents. The pooled group included 273 children and adolescents with bipolar disorder (BD), divided into 2 subgroups: those with (n = 132), and those without (n = 14 1), ADHD comorbidity. Results: There was a moderate and significant reduction in relative risk (RR) favouring treatment response in children and adolescents with BD but without ADHD comorbidity (RR 0.822; 95%Cl, 0.69 to 0.97; P = 0.021). The negative effect of ADHD comorbidity on treatment response was more significant in studies including adolescents only or subjects with BD I only. Conclusion: These findings suggest that children and adolescents with BD and ADHD tend to be less responsive to drugs used in treatment of acute mania.
引用
收藏
页码:323 / 328
页数:6
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