Direct asymmetric aldol reactions catalyzed by (4S)-phenoxy-(S)-proline

被引：0

作者：

Shen, ZX ^{[1
]}

Zhou, H ^{[1
]}

Ma, JM ^{[1
]}

Liu, YH ^{[1
]}

Zhang, YW ^{[1
]}

机构：

[1] Suzhou Univ, Coll Chem & Chem Engn, Key Lab Organ Synth Jiangsu Prov, Suzhou 215006, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 24卷 / 10期

关键词：

aldol reaction; catalysis; asymmetric;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Mitsunobu reaction of N-ethoxycarbonyl-(4R)-hydroxy-(S)-proline methyl ester with phenol afforded (4S)-phenoxy-(S)-proline methyl. ester, which, after saponification and hydrolysis in hydrochloric acid, gave the title amino acid. This compound (5 mol%) catalyzes aldol reaction of acetone with benzaldehydes enantioselectively in the yields ranging from 67.4% to 89.9%, with the ee up to 76.5%.

引用

页码：1213 / 1216

页数：4

共 12 条

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