Amyloid precursor protein and amyloid precursor-like protein 2 in cancer

被引：76

作者：

Pandey, Poomy ^{[1
]}

Sliker, Bailee ^{[1
]}

Peters, Haley L. ^{[1
,6
]}

Tuli, Amit ^{[1
,2
,7
]}

Herskovitz, Jonathan ^{[1
]}

Smits, Kaitlin ^{[1
]}

Purohit, Abhilasha ^{[3
]}

Singh, Rakesh K. ^{[3
,4
]}

Dong, Jixin ^{[1
,4
]}

Batra, Surinder K. ^{[2
,4
]}

Coulter, Donald W. ^{[4
,5
]}

Solheim, Joyce C. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Nebraska Med Ctr, Eppley Inst Res Canc & Allied Dis, Omaha, NE USA

[2] Univ Nebraska Med Ctr, Dept Biochem & Mol Biol, Omaha, NE USA

[3] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE USA

[4] Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE USA

[5] Univ Nebraska Med Ctr, Dept Pediat, Omaha, NE USA

[6] Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Houston, TX 77030 USA

[7] CSIR Inst Microbial Technol, Chandigarh, India

来源：

ONCOTARGET | 2016年 / 7卷 / 15期

基金：

英国惠康基金;

关键词：

amyloid precursor protein; amyloid precursor-like protein 2; cancer; growth; migration; CHONDROITIN SULFATE GLYCOSAMINOGLYCAN; ALTERNATIVE SPLICING MARKERS; ALZHEIMERS-DISEASE; PANCREATIC-CANCER; MESSENGER-RNA; CELL-PROLIFERATION; GENE-EXPRESSION; I RECEPTOR; CHROMOSOMAL LOCALIZATION; INHIBITOR DOMAIN;

D O I：

10.18632/oncotarget.7103

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Amyloid precursor protein (APP) and its family members amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are type 1 transmembrane glycoproteins that are highly conserved across species. The transcriptional regulation of APP and APLP2 is similar but not identical, and the cleavage of both proteins is regulated by phosphorylation. APP has been implicated in Alzheimer's disease causation, and in addition to its importance in neurology, APP is deregulated in cancer cells. APLP2 is likewise overexpressed in cancer cells, and APLP2 and APP are linked to increased tumor cell proliferation, migration, and invasion. In this present review, we discuss the unfolding account of these APP family members' roles in cancer progression and metastasis.

引用

页码：19430 / 19444

页数：15

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