A Tryptophan-Deficient Diet Induces Gut Microbiota Dysbiosis and Increases Systemic Inflammation in Aged Mice

被引:42
|
作者
Yusufu, Ibrahim [1 ]
Ding, Kehong [1 ]
Smith, Kathryn [2 ]
Wankhade, Umesh D. [3 ,4 ]
Sahay, Bikash [5 ]
Patterson, G. Taylor [1 ]
Pacholczyk, Rafal [6 ]
Adusumilli, Satish [7 ]
Hamrick, Mark W. [2 ,8 ]
Hill, William D. [9 ,10 ]
Isales, Carlos M. [1 ,8 ]
Fulzele, Sadanand [1 ,2 ,8 ]
机构
[1] Augusta Univ, Dept Med, Augusta, GA 30912 USA
[2] Augusta Univ, Dept Cell Biol & Anat, Augusta, GA 30912 USA
[3] Univ Arkansas Med Sci UAMS, Coll Med, Dept Pediat, Little Rock, AR 72202 USA
[4] Arkansas Childrens Res Inst, Arkansas Children Nutr Ctr, Little Rock, AR 72202 USA
[5] Univ Florida, Dept Infect Dis & Immunol, Gainesville, FL 32608 USA
[6] Augusta Univ, Georgia Canc Ctr, Augusta, GA 30902 USA
[7] Univ Notre Dame, Dept Pathol, Notre Dame, IN 46556 USA
[8] Augusta Univ, Inst Hlth Aging, Augusta, GA 30912 USA
[9] Med Univ South Carolina, Dept Pathol, Charleston, SC 29403 USA
[10] Ralph H Johnson Vet Affairs Med Ctr, Charleston, SC 29403 USA
基金
美国国家卫生研究院;
关键词
tryptophan; systemic inflammation; dysbiosis; gut; microbiota; METABOLISM; INDUCTION; INDOLE;
D O I
10.3390/ijms22095005
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The gut microflora is a vital component of the gastrointestinal (GI) system that regulates local and systemic immunity, inflammatory response, the digestive system, and overall health. Older people commonly suffer from inadequate nutrition or poor diets, which could potentially alter the gut microbiota. The essential amino acid (AA) tryptophan (TRP) is a vital diet component that plays a critical role in physiological stress responses, neuropsychiatric health, oxidative systems, inflammatory responses, and GI health. The present study investigates the relationship between varied TRP diets, the gut microbiome, and inflammatory responses in an aged mouse model. We fed aged mice either a TRP-deficient (0.1%), TRP-recommended (0.2%), or high-TRP (1.25%) diet for eight weeks and observed changes in the gut bacterial environment and the inflammatory responses via cytokine analysis (IL-1a, IL-6, IL-17A, and IL-27). The mice on the TRP-deficient diets showed changes in their bacterial abundance of Coriobacteriia class, Acetatifactor genus, Lachnospiraceae family, Enterococcus faecalis species, Clostridium sp genus, and Oscillibacter genus. Further, these mice showed significant increases in IL-6, IL-17A, and IL-1a and decreased IL-27 levels. These data suggest a direct association between dietary TRP content, the gut microbiota microenvironment, and inflammatory responses in aged mice models.
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页数:12
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