A review: recent advances and future prospects of taxol-producing endophytic fungi

被引:142
|
作者
Zhou, Xuanwei [1 ]
Zhu, Huifang [1 ]
Liu, Lu [2 ]
Lin, Juan [2 ]
Tang, Kexuan [1 ]
机构
[1] Shanghai Jiao Tong Univ, Plant Biotechnol Res Ctr, Sch Agr & Biol, Fudan SJTU Nottingham Plant Biotechnol R&D Ctr, Shanghai 200240, Peoples R China
[2] Fudan Univ, Sch Life Sci,Morgan Tan Int Ctr Life Sci, State Key Lab Genet Engn, Fudan SJTU Nottingham Plant Biotechnol R&D Ctr, Shanghai 200240, Peoples R China
关键词
Taxol; Endophytic fungi; Isolation; Identification; Meliorate; FUSARIUM-SPOROTRICHIOIDES; MOLECULAR-CLONING; PROTOPLAST FUSION; IDENTIFICATION; BIOSYNTHESIS; TRANSFORMATION; RECOMBINATION; LANGSETHIAE; INTEGRATION; PHYLOGENY;
D O I
10.1007/s00253-010-2546-y
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
In the urgent search for more effective ways to treat cancer, new extraction methods of taxol from endophytic fungus have demonstrated high potential in increasing the efficiency of taxol extraction for more efficient and sustainable production of taxol and cancer treatment products. This paper summarizes recent advances in taxol-producing endophytic fungi, both in China and abroad, in the following areas: isolation and identification of endophytic fungi types, extraction and detection methods of endophytic taxol in plants, and improved efficiency of the extraction process. With the advancement of science and technology, new techniques in biotechnology, such as fungal strain improvement and recombining technique and microbial fermentation engineering, have increased the extraction yield from taxol-producing fungi, thereby improved the overall efficiency of taxol production.
引用
收藏
页码:1707 / 1717
页数:11
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