Roxadustat and thyroid-stimulating hormone suppression

被引：28
|
作者：
Tokuyama, Atsuyuki [1 ]
Kadoya, Hiroyuki [1 ]
Obata, Atsushi [2 ,3 ]
Obata, Takahiro [3 ]
Sasaki, Tamaki [1 ]
Kashihara, Naoki [1 ]
机构：
[1] Kawasaki Med Sch, Dept Nephrol & Hypertens, Okayama, Japan
[2] Kawasaki Med Sch, Dept Diabet Endocrinol & Metab, Okayama, Japan
[3] Obata Med Clin, Okayama, Japan
来源：
CLINICAL KIDNEY JOURNAL | 2021年 / 14卷 / 05期
关键词：
end-stage renal disease; hemodialysis; hypothyroidism; hypoxia-inducible factor prolyl-hydroxylase inhibitor; levothyroxine sodium hydrate; roxadustat; ANEMIA;
D O I：
10.1093/ckj/sfab007
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Hypoxia-inducible factor prolyl-hydroxylase inhibitors belong to a new class of orally administered drugs for treating anemia in patients with chronic kidney disease (CKD). The prevalence of hypothyroidism is disproportionately high in patients with CKD on hemodialysis. We report a rapid suppression of thyroid-stimulating hormone (TSH) and decrease in free triiodothyronine (T3) and free tetraiodothyronine levels after switching from darbepoetin alfa to roxadustat in a hemodialysis patient with hypothyroidism on levothyroxine therapy. This was reversed after stopping roxadustat. Roxadustat has structural similarity with T3 and is a selective activating ligand for thyroid hormone receptor-beta possibly suppressing TSH release.
引用
收藏
页码：1472 / 1474
页数：3
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