Serum lipids and hippocampal volume: The link to Alzheimer's disease?

被引：90
|
作者：
Wolf, H
Hensel, A
Arendt, T
Kivipelto, M
Winblad, B
Gertz, HJ
机构：
[1] Karolinska Inst, Dept Neurotec, Div Clin Geriatr, Aging Res Ctr, S-11382 Stockholm, Sweden
[2] Univ Leipzig, Dept Psychiat, Leipzig, Germany
[3] Univ Leipzig, Paul Flechsig Inst Brain Res, Leipzig, Germany
来源：
ANNALS OF NEUROLOGY | 2004年 / 56卷 / 05期
关键词：
D O I：
10.1002/ana.20289
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The association between hippocampal volume (as a presumed index of Alzheimer's disease pathology) with serum total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol was studied in 86 elderly subjects with a range of cognitive functions. High-density lipoprotein cholesterol, but not low-density lipoprotein cholesterol or total cholesterol, was associated with hippocampal volume and dementia. This is compatible with protective effects of high-density lipoprotein cholesterol on hippocampal atrophy and Alzheimer's disease.
引用
收藏
页码：745 / 748
页数：4
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