Ovarian cancer stem cells and targeted therapy

被引：75
|
作者：
Keyvani, Vahideh [1 ,2 ]
Farshchian, Moein [3 ]
Esmaeili, Seyed-Alireza [4 ,5 ]
Yari, Hadi [6 ]
Moghbeli, Meysam [2 ]
Nezhad, Seyed-Reza Kazemi [2 ]
Abbaszadegan, Mohammad Reza [1 ]
机构：
[1] Mashhad Univ Med Sci, Med Genet Res Ctr, Mashhad, Razavi Khorasan, Iran
[2] Shahid Chamran Univ Ahvaz, Dept Biol, Fac Sci, Ahvaz, Iran
[3] Acad Ctr Educ Culture & Res ACECR, Khorasan Razavi Branch, Stem Cell & Regenerat Med Res Grp, Mashhad, Razavi Khorasan, Iran
[4] Mashhad Univ Med Sci, Immunol Res Ctr, Bu Ali Res Inst, Mashhad, Razavi Khorasan, Iran
[5] Mashhad Univ Med Sci, Fac Med, Dept Immunol, Mashhad, Razavi Khorasan, Iran
[6] Natl Inst Genet Engn & Biotechnol, Div Human Genet, Med Biotechnol Dept, Tehran, Iran
来源：
JOURNAL OF OVARIAN RESEARCH | 2019年 / 12卷 / 01期
关键词：
Cancer stem cell; Ovarian cancer; Isolation; Detection; Drug resistance; BCL-X-L; EPITHELIAL OVARIAN; SELF-RENEWAL; HEDGEHOG PATHWAY; IN-VITRO; INTRAEPITHELIAL CARCINOMA; SIGNALING PATHWAY; INITIATING CELLS; SEROUS CARCINOMA; SIDE-POPULATION;
D O I：
10.1186/s13048-019-0588-z
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Background Ovarian cancer has the highest ratio of mortality among gynecologic malignancies. Chemotherapy is one of the most common treatment options for ovarian cancer. However, tumor relapse in patients with advanced tumor stage is still a therapeutic challenge for its clinical management. Main body Therefore, it is required to clarify the molecular biology and mechanisms which are involved in chemo resistance to improve the survival rate of ovarian cancer patients. Cancer stem cells (CSCs) are a sub population of tumor cells which are related to drug resistance and tumor relapse. Conclusion In the present review, we summarized the recent findings about the role of CSCs in tumor relapse and drug resistance among ovarian cancer patients. Moreover, we focused on the targeted and combinational therapeutic methods against the ovarian CSCs.
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页数：11
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