Combinatorial Relief of Multiple Innate Immune Blocks Allows Efficient Gene Engineering of Quiescent Human Hematopoietic Stem Cells

被引：0
|
作者：
Valeri, Erika [1 ,2 ]
Unali, Giulia [1 ,2 ]
Piras, Francesco [1 ]
Cuccovillo, Ivan [1 ]
Landau, Nathaniel R. [3 ]
Kajaste-Rudnitski, Anna [1 ]
机构：
[1] IRCCS San Raffaele Sci Inst, San Raffaele Telethon Inst Gene Therapy, Milan, Italy
[2] Univ Vita Salute San Raffaele, Sch Med, Milan, Italy
[3] NYU, Sch Med, Dept Microbiol, New York, NY 10016 USA
来源：
MOLECULAR THERAPY | 2021年 / 29卷 / 04期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
257
引用
收藏
页码：132 / 133
页数：2
相关论文
共 50 条
  • [1] Exploring combinatorial relief of multiple innate immune blocks for efficient gene engineering of quiescent human hematopoietic stem cells
    Piras, F.
    Valeri, E.
    Unali, G.
    Cuccovillo, I.
    Landau, N. R.
    Kajaste-Rudnitski, A.
    [J]. HUMAN GENE THERAPY, 2019, 30 (11) : A193 - A194
  • [2] Removal of innate immune barriers allows efficient transduction of quiescent human hematopoietic stem cells
    Valeri, Erika
    Unali, Giulia
    Piras, Francesco
    Abou-Alezz, Monah
    Pais, Giulia
    Benedicenti, Fabrizio
    Lidonnici, Maria Rosa
    Cuccovillo, Ivan
    Castiglioni, Ilaria
    Arevalo, Sergio
    Spinozzi, Giulio
    Merelli, Ivan
    Behrendt, Rayk
    Oo, Adrian
    Kim, Baek
    Landau, Nathaniel R.
    Ferrari, Giuliana
    Montini, Eugenio
    Kajaste-Rudnitski, Anna
    [J]. MOLECULAR THERAPY, 2024, 32 (01) : 124 - 139
  • [3] COMBINATORIAL GENE TARGETING IN PRIMARY HUMAN HEMATOPOIETIC STEM AND PROGENITOR CELLS
    Backstrom, Alexandra
    Yudovich, David
    Zemaitis, Kristijonas
    Falck, Ludvig Nilsen
    Subramaniam, Agatheeswaran
    Larsson, Jonas
    [J]. EXPERIMENTAL HEMATOLOGY, 2022, 111 : S59 - S59
  • [4] Combinatorial gene targeting in primary human hematopoietic stem and progenitor cells
    Alexandra Bäckström
    David Yudovich
    Kristijonas Žemaitis
    Ludvig Nilsén Falck
    Agatheeswaran Subramaniam
    Jonas Larsson
    [J]. Scientific Reports, 12
  • [5] Combinatorial gene targeting in primary human hematopoietic stem and progenitor cells
    Backstrom, Alexandra
    Yudovich, David
    Zemaitis, Kristijonas
    Falck, Ludvig Nilsen
    Subramaniam, Agatheeswaran
    Larsson, Jonas
    [J]. SCIENTIFIC REPORTS, 2022, 12 (01)
  • [6] Dissecting Immunomodulatory Relief of Lentiviral Restriction in Human Hematopoietic Stem and Progenitor Cells for Efficient Gene Transfer
    Petrillo, Carolina
    Cesana, Daniela
    Piras, Francesco
    Naldini, Luigi
    Montini, Eugenio
    Kajaste-Rudnitski, Anna
    [J]. MOLECULAR THERAPY, 2014, 22 : S205 - S205
  • [7] Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells
    Petrillo, Carolina
    Thorne, Lucy G.
    Unali, Giulia
    Schiroli, Giulia
    Giordano, Anna M. S.
    Piras, Francesco
    Cuccovillo, Ivan
    Petit, Sarah J.
    Ahsan, Fatima
    Noursadeghi, Mandad
    Clare, Simon
    Genovese, Pietro
    Gentner, Bernhard
    Naldini, Luigi
    Towers, Greg J.
    Kajaste-Rudnitski, Anna
    [J]. CELL STEM CELL, 2018, 23 (06) : 820 - +
  • [8] Gene Delivery Using Baculovirus in Human Hematopoietic Stem and Progenitor Cells Requires Inhibition of Cellular Innate Immune Pathways
    Salisbury-Ruf, Christi
    Smith, Richard H.
    Chinian, Fariba
    Araki, Daisuke
    Keyvanfar, Keyvan
    Larochelle, Andre
    [J]. BLOOD, 2021, 138
  • [9] Highly efficient therapeutic gene editing of human hematopoietic stem cells
    Yuxuan Wu
    Jing Zeng
    Benjamin P. Roscoe
    Pengpeng Liu
    Qiuming Yao
    Cicera R. Lazzarotto
    Kendell Clement
    Mitchel A. Cole
    Kevin Luk
    Cristina Baricordi
    Anne H. Shen
    Chunyan Ren
    Erica B. Esrick
    John P. Manis
    David M. Dorfman
    David A. Williams
    Alessandra Biffi
    Carlo Brugnara
    Luca Biasco
    Christian Brendel
    Luca Pinello
    Shengdar Q. Tsai
    Scot A. Wolfe
    Daniel E. Bauer
    [J]. Nature Medicine, 2019, 25 : 776 - 783
  • [10] Highly efficient therapeutic gene editing of human hematopoietic stem cells
    Wu, Yuxuan
    Zeng, Jing
    Roscoe, Benjamin P.
    Liu, Pengpeng
    Yao, Qiuming
    Lazzarotto, Cicera R.
    Clement, Kendell
    Cole, Mitchel A.
    Luk, Kevin
    Baricordi, Cristina
    Shen, Anne H.
    Ren, Chunyan
    Esrick, Erica B.
    Manis, John P.
    Dorfman, David M.
    Williams, David A.
    Biffi, Alessandra
    Brugnara, Carlo
    Biasco, Luca
    Brendel, Christian
    Pinello, Luca
    Tsai, Shengdar Q.
    Wolfe, Scot A.
    Bauer, Daniel E.
    [J]. NATURE MEDICINE, 2019, 25 (05) : 776 - +
12345